(1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

Base Information

Chemical Name:(1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane
CAS No.:1076206-64-8
Molecular Formula:C₁₉H₁₉F₃N₂O₂S
Molecular Weight:396.433
Hs Code.:

Synonyms:(1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

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Chemical Property of (1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

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Technology Process of (1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

There total 10 articles about (1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 244022-72-8
(2,3,5-trifluorophenyl)methanamine

: 116143-09-0
(3S,5R)-1-[(4-methylphenyl)sulfonyl]-3-[(4-methylphenyl)sulfonyloxy]-5-[(4-methylphenyl)sulfonyloxymethyl]pyrrolidine

: 1076206-64-8
(1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

Guidance literature:: In toluene; for 156h; Heating / reflux;

Reference yield:

: 1075183-51-5
N-tosyl hydroxyproline methyl ester

: 1076206-64-8
(1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole

2.1: potassium hydroxide; water

3.1: dicyclohexyl-carbodiimide

4.1: lithium aluminium tetrahydride / tetrahydrofuran

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / -40 °C

5.2: -40 - 20 °C

6.1: hydrogenchloride; ethanol; water / 5 h / 20 °C

7.1: pyridine / 92 h / 0 - 20 °C

8.1: toluene / 156 h / Heating / reflux

With pyridine; 1H-imidazole; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; ethanol; water; dicyclohexyl-carbodiimide; In tetrahydrofuran; toluene;

Reference yield:

: 142928-26-5
(2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<(3,5-dimethyl-1H-pyrazol-1-yl)-carbonyl>pyrrolidine

: 1076206-64-8
(1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / -40 °C

2.2: -40 - 20 °C

3.1: hydrogenchloride; ethanol; water / 5 h / 20 °C

4.1: pyridine / 92 h / 0 - 20 °C

5.1: toluene / 156 h / Heating / reflux

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; ethanol; water; In tetrahydrofuran; toluene;