(2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol

Base Information

Chemical Name:(2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol
CAS No.:1076206-60-4
Molecular Formula:C₁₈H₃₁NO₄SSi
Molecular Weight:385.6
Hs Code.:

Synonyms:(2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol

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Chemical Property of (2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol

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Technology Process of (2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol

There total 9 articles about (2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141621-10-5
(2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine

: 1076206-60-4
(2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol

Guidance literature:: (2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine; With lithium aluminium tetrahydride; In tetrahydrofuran; at -40 ℃; for 1.5h;

With water; In tetrahydrofuran; at -40 - 20 ℃;

Reference yield:

: 1075183-51-5
N-tosyl hydroxyproline methyl ester

: 1076206-60-4
(2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole

2.1: potassium hydroxide; water

3.1: dicyclohexyl-carbodiimide

4.1: lithium aluminium tetrahydride / tetrahydrofuran

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / -40 °C

5.2: -40 - 20 °C

With 1H-imidazole; potassium hydroxide; lithium aluminium tetrahydride; water; dicyclohexyl-carbodiimide; In tetrahydrofuran;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1076206-60-4
(2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole

2.1: potassium hydroxide; water

3.1: dicyclohexyl-carbodiimide

4.1: lithium aluminium tetrahydride / tetrahydrofuran

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / -40 °C

5.2: -40 - 20 °C

With 1H-imidazole; potassium hydroxide; lithium aluminium tetrahydride; water; dicyclohexyl-carbodiimide; In tetrahydrofuran;