tert-butyl 2-tert-butyl-5-aminobenzylcarbamate

Base Information

Chemical Name:tert-butyl 2-tert-butyl-5-aminobenzylcarbamate
CAS No.:873056-32-7
Molecular Formula:C₁₆H₂₆N₂O₂
Molecular Weight:278.395
Hs Code.:

Synonyms:tert-butyl 2-tert-butyl-5-aminobenzylcarbamate

Suppliers and Price of tert-butyl 2-tert-butyl-5-aminobenzylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of tert-butyl 2-tert-butyl-5-aminobenzylcarbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 2-tert-butyl-5-aminobenzylcarbamate

There total 5 articles about tert-butyl 2-tert-butyl-5-aminobenzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 873056-31-6
tert-butyl 2-tert-butyl-5-nitrobenzylcarbamate

: 873056-32-7
tert-butyl 2-tert-butyl-5-aminobenzylcarbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm5012808

Reference yield:

: 6310-17-4
2-bromo-1-tert-butyl-4-nitrobenzene

: 873056-32-7
tert-butyl 2-tert-butyl-5-aminobenzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / Sealed tube; Inert atmosphere; Heating

2.1: diborane / tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

2.2: 0 °C / Reflux

3.1: tetrahydrofuran / 0.5 h / 70 °C

4.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 1 h / 25 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; acetic acid; diborane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm5012808

Reference yield:

: 3282-56-2
4-tert-butylnitrobenzene

: 873056-32-7
tert-butyl 2-tert-butyl-5-aminobenzylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; silver(II) sulfate; bromine / 16 h / 25 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / Sealed tube; Inert atmosphere; Heating

3.1: diborane / tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

3.2: 0 °C / Reflux

4.1: tetrahydrofuran / 0.5 h / 70 °C

5.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 1 h / 25 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver(II) sulfate; sulfuric acid; palladium 10% on activated carbon; hydrogen; bromine; acetic acid; diborane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm5012808