[5-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-2-tert-butylphenyl]methylaminoformic acid tert-butyl ester

Base Information

Chemical Name:[5-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-2-tert-butylphenyl]methylaminoformic acid tert-butyl ester
CAS No.:873054-75-2
Molecular Formula:C₂₆H₃₁N₃O₄
Molecular Weight:449.55
Hs Code.:

Synonyms:[5-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-2-tert-butylphenyl]methylaminoformic acid tert-butyl ester

Suppliers and Price of [5-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-2-tert-butylphenyl]methylaminoformic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [5-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-2-tert-butylphenyl]methylaminoformic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [5-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-2-tert-butylphenyl]methylaminoformic acid tert-butyl ester

There total 5 articles about [5-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-2-tert-butylphenyl]methylaminoformic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873056-32-7
tert-butyl 2-tert-butyl-5-aminobenzylcarbamate

: 13721-01-2
4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 873054-75-2
[5-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-2-tert-butylphenyl]methylaminoformic acid tert-butyl ester

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 60 ℃; for 16h;
DOI:10.1021/jm5012808

Reference yield:

: 3282-56-2
4-tert-butylnitrobenzene

: 873054-75-2
[5-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-2-tert-butylphenyl]methylaminoformic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; silver(II) sulfate; bromine / 16 h / 25 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / Sealed tube; Inert atmosphere; Heating

3.1: diborane / tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

3.2: 0 °C / Reflux

4.1: tetrahydrofuran / 0.5 h / 70 °C

5.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 1 h / 25 °C / Inert atmosphere

6.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / dichloromethane / 16 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver(II) sulfate; sulfuric acid; palladium 10% on activated carbon; hydrogen; bromine; acetic acid; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; diborane; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm5012808

Reference yield:

: 873056-30-5
(2-tert-butyl-5-nitrophenyl)methanamine

: 873054-75-2
[5-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-2-tert-butylphenyl]methylaminoformic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.5 h / 70 °C

2: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 1 h / 25 °C / Inert atmosphere

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / dichloromethane / 16 h / 60 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm5012808