2-(1,1-dimethylethyl)-2-methyl-1-[(4-methylphenyl)sulfonyl]aziridine

Base Information

• Chemical Name: 2-(1,1-dimethylethyl)-2-methyl-1-[(4-methylphenyl)sulfonyl]aziridine
• CAS No.: 1207754-77-5
• Molecular Formula: C₁₄H₂₁NO₂S
• Molecular Weight: 267.392
• Mol file: 1207754-77-5.mol

Synonyms:2-(1,1-dimethylethyl)-2-methyl-1-[(4-methylphenyl)sulfonyl]aziridine

Chemical Property of 2-(1,1-dimethylethyl)-2-methyl-1-[(4-methylphenyl)sulfonyl]aziridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1,1-dimethylethyl)-2-methyl-1-[(4-methylphenyl)sulfonyl]aziridine

There total 2 articles about 2-(1,1-dimethylethyl)-2-methyl-1-[(4-methylphenyl)sulfonyl]aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2,2,3-trimethylbut-1-ene (594-56-9) + chloroamine-T (127-65-1) → 2-(1,1-dimethylethyl)-2-methyl-1-[(4-methylphenyl)sulfonyl]aziridine (1207754-77-5)

Guidance literature:

With phenyltrimethylammonium tribromide; In acetonitrile; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.bmcl.2020.127661

Reference yield: 54.0%

2,2,3-trimethylbut-1-ene (594-56-9) → 2-(1,1-dimethylethyl)-2-methyl-1-[(4-methylphenyl)sulfonyl]aziridine (1207754-77-5)

Guidance literature:

With chloroamine-T; In acetonitrile; for 20h; Inert atmosphere;

DOI:10.1016/j.bmcl.2020.127357

Reference yield: 17.9%

2-(1,1-dimethylethyl)-2-methyl-1-[(4-methylphenyl)sulfonyl]aziridine (1207754-77-5) + benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-hydroxy-14-methoxy-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate (956102-56-0) → benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-15-[[(2S)-2,3,3-trimethyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate (1207755-37-0) + benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-15-[[(2R)-2,3,3-trimethyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate (1207755-36-9)

Guidance literature:

With 18-crown-6 ether; potassium hydride; In 1,2-dimethoxyethane; toluene; mineral oil; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmcl.2020.127661

upstream raw materials:

2,2,3-trimethylbut-1-ene

chloroamine-T

Downstream raw materials:

benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-15-[[(2S)-2,3,3-trimethyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate

benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-15-[[(2R)-2,3,3-trimethyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate