(S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate

Base Information

Chemical Name:(S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate
CAS No.:1383801-14-6
Molecular Formula:C₂₄H₂₄F₃N₃O₂
Molecular Weight:443.469
Hs Code.:

Synonyms:(S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate

Suppliers and Price of (S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate

There total 7 articles about (S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1383801-11-3
(S)-3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butan-1-amine

: 1427-06-1
methyl 6-fluoropyridine-3-carboxylate

: 1383801-14-6
(S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate

Guidance literature:: With potassium phosphate; In N,N-dimethyl acetamide; at 107 - 110 ℃; for 24h;

Reference yield:

: 87199-17-5
4-formylphenylboronic acid,

: 1383801-14-6
(S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / acetonitrile / 3 h / Inert atmosphere; Reflux

2.1: titanium(IV) tetraethanolate / dichloromethane / 12.5 h / 20 °C / Inert atmosphere; Reflux

3.1: zinc(II) chloride / ethyl acetate; n-heptane; diethyl ether; water; tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

3.3: -78 - 20 °C

4.1: hydrogenchloride / diethyl ether; methanol / 1 h / 0 - 15 °C

5.1: potassium phosphate / N,N-dimethyl acetamide / 24 h / 107 - 110 °C

With hydrogenchloride; titanium(IV) tetraethanolate; potassium phosphate; sodium carbonate; zinc(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; diethyl ether; n-heptane; dichloromethane; N,N-dimethyl acetamide; water; ethyl acetate; acetonitrile;

Reference yield:

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1383801-14-6
(S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / acetonitrile / 3 h / Inert atmosphere; Reflux

2.1: titanium(IV) tetraethanolate / dichloromethane / 12.5 h / 20 °C / Inert atmosphere; Reflux

3.1: zinc(II) chloride / ethyl acetate; n-heptane; diethyl ether; water; tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

3.3: -78 - 20 °C

4.1: hydrogenchloride / diethyl ether; methanol / 1 h / 0 - 15 °C

5.1: potassium phosphate / N,N-dimethyl acetamide / 24 h / 107 - 110 °C

With hydrogenchloride; titanium(IV) tetraethanolate; potassium phosphate; sodium carbonate; zinc(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; diethyl ether; n-heptane; dichloromethane; N,N-dimethyl acetamide; water; ethyl acetate; acetonitrile;