Technology Process of (S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate
There total 7 articles about (S)-methyl 6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium phosphate;
In
N,N-dimethyl acetamide;
at 107 - 110 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / acetonitrile / 3 h / Inert atmosphere; Reflux
2.1: titanium(IV) tetraethanolate / dichloromethane / 12.5 h / 20 °C / Inert atmosphere; Reflux
3.1: zinc(II) chloride / ethyl acetate; n-heptane; diethyl ether; water; tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
3.2: 0.5 h / -78 °C / Inert atmosphere
3.3: -78 - 20 °C
4.1: hydrogenchloride / diethyl ether; methanol / 1 h / 0 - 15 °C
5.1: potassium phosphate / N,N-dimethyl acetamide / 24 h / 107 - 110 °C
With
hydrogenchloride; titanium(IV) tetraethanolate; potassium phosphate; sodium carbonate; zinc(II) chloride;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; methanol; diethyl ether; n-heptane; dichloromethane; N,N-dimethyl acetamide; water; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / acetonitrile / 3 h / Inert atmosphere; Reflux
2.1: titanium(IV) tetraethanolate / dichloromethane / 12.5 h / 20 °C / Inert atmosphere; Reflux
3.1: zinc(II) chloride / ethyl acetate; n-heptane; diethyl ether; water; tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
3.2: 0.5 h / -78 °C / Inert atmosphere
3.3: -78 - 20 °C
4.1: hydrogenchloride / diethyl ether; methanol / 1 h / 0 - 15 °C
5.1: potassium phosphate / N,N-dimethyl acetamide / 24 h / 107 - 110 °C
With
hydrogenchloride; titanium(IV) tetraethanolate; potassium phosphate; sodium carbonate; zinc(II) chloride;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; methanol; diethyl ether; n-heptane; dichloromethane; N,N-dimethyl acetamide; water; ethyl acetate; acetonitrile;