(2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid

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Chemical Name:(2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid
CAS No.:1349091-91-3
Molecular Formula:C₃₀H₃₁N₃O₅
Molecular Weight:513.593
Hs Code.:

Synonyms:(2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid

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Chemical Property of (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid

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Technology Process of (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid

There total 6 articles about (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1612149-03-7
tert-butyl (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoate

: 1349091-91-3
(2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm5003843

Reference yield: 53.0%

: 1349091-91-3
(2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1612148-76-1
methyl 5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazole-3-carboxylate

: 1349091-91-3
(2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm5003843