tert-butyl (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoate

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Chemical Name:tert-butyl (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoate
CAS No.:1612149-03-7
Molecular Formula:C₃₄H₃₉N₃O₅
Molecular Weight:569.701
Hs Code.:

Synonyms:tert-butyl (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoate

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Chemical Property of tert-butyl (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoate

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Technology Process of tert-butyl (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoate

There total 5 articles about tert-butyl (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 213475-52-6
tert-butyl (2S)-amino(cyclohexyl)ethanoate hydrochloride

: 1146758-08-8
5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazole-3-carboxylic acid

: 1612149-03-7
tert-butyl (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm5003843

Reference yield: 53.0%

: 1612149-03-7
tert-butyl (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; for 16h; Inert atmosphere;

Reference yield:

: 1612148-76-1
methyl 5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazole-3-carboxylate

: 1612149-03-7
tert-butyl (2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm5003843