8-(4-Chloro-phenoxy)-2-methylene-octanoyl chloride

Base Information

• Chemical Name: 8-(4-Chloro-phenoxy)-2-methylene-octanoyl chloride
• CAS No.: 124083-16-5
• Molecular Formula: C₁₅H₁₈Cl₂O₂
• Molecular Weight: 301.213
• Mol file: 124083-16-5.mol

Synonyms:8-(4-Chloro-phenoxy)-2-methylene-octanoyl chloride

Chemical Property of 8-(4-Chloro-phenoxy)-2-methylene-octanoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 8-(4-Chloro-phenoxy)-2-methylene-octanoyl chloride

There total 2 articles about 8-(4-Chloro-phenoxy)-2-methylene-octanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

8-(4-Chloro-phenoxy)-2-methylene-octanoic acid (124083-17-6) → 8-(4-Chloro-phenoxy)-2-methylene-octanoyl chloride (124083-16-5)

Guidance literature:

With thionyl chloride; for 18h; from 0 deg C to room temp.;

DOI:10.1016/S0040-4039(01)80643-2

Reference yield:

ethyl 2-[6-(p-chlorophenoxy)hexyl]acrylate (82258-37-5) → 8-(4-Chloro-phenoxy)-2-methylene-octanoyl chloride (124083-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 25percent NaOH / methanol / 18 h / Ambient temperature

2: 63 percent / SOCl₂ / 18 h / from 0 deg C to room temp.

With sodium hydroxide; thionyl chloride; In methanol;

DOI:10.1016/S0040-4039(01)80643-2

Reference yield: 60.0%

8-(4-Chloro-phenoxy)-2-methylene-octanoyl chloride (124083-16-5) → 8-(4-Chloro-phenoxy)-2-methylene-octan-1-ol (124083-15-4)

Guidance literature:

With sodium tetrahydroborate; silica gel; In diethyl ether; for 18h; Ambient temperature;

DOI:10.1016/S0040-4039(01)80643-2

upstream raw materials:

8-(4-Chloro-phenoxy)-2-methylene-octanoic acid

ethyl 2-[6-(p-chlorophenoxy)hexyl]acrylate

Downstream raw materials:

8-(4-Chloro-phenoxy)-2-methylene-octan-1-ol

7-(4-chlorophenoxy)heptanoic acid

{(S)-2-[6-(4-Chloro-phenoxy)-hexyl]-oxiranyl}-methanol

{(R)-2-[6-(4-Chloro-phenoxy)-hexyl]-oxiranyl}-methanol

Refernces