Piconol

Base Information

• Chemical Name: Piconol
• CAS No.: 586-98-1
• Molecular Formula: C6H7NO
• Molecular Weight: 109.128
• Hs Code.: 29333999
• European Community (EC) Number: 209-592-7
• NSC Number: 760363
• UNII: 7HQ8UT1TPS
• DSSTox Substance ID: DTXSID8046531
• Nikkaji Number: J32.889H
• Wikidata: Q27268311
• NCI Thesaurus Code: C76723
• ChEMBL ID: CHEMBL2103981
• Mol file: 586-98-1.mol

Synonyms:2-PYRIDINEMETHANOL;586-98-1;pyridin-2-ylmethanol;2-(Hydroxymethyl)pyridine;Piconol;2-Pyridylmethanol;2-Pyridinylmethanol;Pyridine-2-methanol;2-Pyridylcarbinol;2-Pyridyl carbinol;Piconol [INN];Pyridine-2-carbinol;alpha-Picolyl alcohol;2-hydroxymethylpyridine;(Pyridin-2-yl)methanol;Piconolum [Latin];2-Pyridine methanol;MFCD00006348;Piconolum;Pyridin-2-Yl-Methanol;pyridine-methanol;2-pyridine-methanol;.alpha.-Picolyl alcohol;EINECS 209-592-7;UNII-7HQ8UT1TPS;7HQ8UT1TPS;NSC-760363;BRN 0107849;DTXSID8046531;NCGC00166075-01;5-21-02-00150 (Beilstein Handbook Reference);DTXCID6026531;Pyridinemethanol;CAS-586-98-1;pyridinyl-methanol;2-pyridinylcarbinol;hydroxymethylpyridine;2-pyridinyl carbinol;pyridine-2-ylmethanol;pyridine-2-yl-methanol;2-hydroxymethyl pyridine;2-hydroxymethyl-pyridine;2-Pyridinemethanol, 98%;2-(hydroxymethyl) pyridine;2-(hydroxymethyl)-pyridine;SCHEMBL29266;2-HYDROMETHYL PYRIDINE;CHEMBL2103981;CHEBI:195070;HMS3264E03;Pharmakon1600-01506166;BCP25788;HY-Y0004;STR00171;Tox21_112305;AC7883;NSC760363;AKOS000249319;Tox21_112305_1;CCG-214048;CS-W020042;FG-0436;NSC 760363;4-(2-Aminoethoxy)-3-methoxybenzoicacid;2-Pyridinemethanol;NCGC00166075-02;AM804089;SY005684;LS-131669;2-hydroxymethylpyridine(pyridine-2-methanol);A8296;FT-0613393;P0556;EN300-18423;AB01563256_01;AE-641/00340018;SR-01000944286;Q-101881;SR-01000944286-1;Q27268311;Z57921252;F0001-1533

Chemical Property of Piconol

Chemical Property:

• Appearance/Colour: Clear colorless to yellow or brown liquid
• Vapor Pressure: 0.0577mmHg at 25°C
• Melting Point: 5 °C
• Refractive Index: n20/D 1.543(lit.)
• Boiling Point: 222.6 °C at 760 mmHg
• PKA: 13.48±0.10(Predicted)
• Flash Point: 81.6 °C
• PSA: 33.12000
• Density: 1.131 g/cm³
• LogP: 0.57390
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: miscible
• Water Solubility.: miscible
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 109.052763847
• Heavy Atom Count: 8
• Complexity: 65.5

Purity/Quality:

98% ^*data from raw suppliers

2-(Hydroxymethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Pyridines
• Canonical SMILES: C1=CC=NC(=C1)CO
• Uses: decongestant A pyridylalcohol with hypoglycemic activity and potential apoptotic effect in human leukemia cells. 2-Pyridinemethanol is used as a pyridylalcohol with hypoglycemic activity.

Technology Process of Piconol

There total 78 articles about Piconol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridine-2-carbaldehyde (1121-60-4) → 2-Hydroxymethylpyridine (586-98-1)

Guidance literature:

With 1-Benzyl-3,5-bis(1-pyrrolidinylcarbonyl)-1,4-dihydropyridine; zinc(II) perchlorate; anionic SDS micelle; In water; at 50 ℃; Rate constant; different Zn(ClO₄)2*6H₂O concentration, in the presence and without of SDS;

DOI:10.1039/c39850000994

Reference yield: 99.0%

ethyl-2-picolinate (2524-52-9,1228273-66-2) → 2-Hydroxymethylpyridine (586-98-1)

Guidance literature:

With C₃₀H₃₄Cl₂N₂P₂Ru; potassium methanolate; hydrogen; In tetrahydrofuran; at 100 ℃; for 24h; under 38002.6 - 76005.1 Torr; Glovebox; Autoclave;

Reference yield: 98.0%

methyl pyridine-2-carboxylate (2459-07-6,260998-83-2) → 2-Hydroxymethylpyridine (586-98-1)

Guidance literature:

With sodium tetrahydroborate; sodium methylate; In methanol; at 25 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.joc.7b02993

upstream raw materials:

2-methylpyridine N-oxide

acetic anhydride

2-(Aminomethyl)pyridine

2-Picolinic acid

Downstream raw materials:

(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid pyridin-2-ylmethyl ester

2-[2-(4-Fluorophenyl)-6-oxo-5-(pyridin-2-ylmethoxycarbonylamino)-1,6-dihydro-1-pyrimidinyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

(Z)-ethyl 3-(pyridin-2-yl)acrylate

(E)-ethyl 3-(2-pyridyl)-propenoate

Refernces

• 1、 Awano, Hiroshi,Tagaki, Waichiro. "Zinc Ion and Micelle Catalysed Reduction of Pyridine-2-carbaldehyde by 1-Dodecyl-3,5-bis(pyrrolidin-1-ylcarbonyl)-1,4-dihydropyridine as a NADH Analogue in Aqueous Media". . p. 994 - 996. Retrieved 1985.
• 2、 Miecznikowski, John R.,Lo, Wayne,Lynn, Matthew A.,O'Loughlin, Brianne E.,Dimarzio, Amanda P.,Martinez, Anthony M.,Lampe, Lorraine,Foley, Kathleen M.,Keilich, Lauren C.,Lisi, George P.,Kwiecien, Daniel J.,Pires, Cristina M.,Kelly, William J.,Kloczko, Nathan F.,Morio, Kaitlyn N.. "Syntheses, characterization, density functional theory calculations, and activity of tridentate SNS zinc pincer complexes". . p. 515 - 524. Retrieved 2011.
• 3、 Hughes,Prince. "-". . p. 719,720-722. Retrieved 1978.
• 4、 -. "STIMULI - OR BIO- RESPONSIVE COPOLYMERS, THE POLYMERSOMES COMPRISING THE SAME AND THEIR USE IN DRUG DELIVERY". Page/Page column 22-23. . Retrieved 2021/06/22.
• 5、 Wang, Rongzhou,Yue, Yuancheng,Qi, Jipeng,Liu, Shiyuan,Song, Ao,Zhuo, Shuping,Xing, Ling-Bao. "Ambient-pressure highly active hydrogenation of ketones and aldehydes catalyzed by a metal-ligand bifunctional iridium catalyst under base-free conditions in water". . p. 1 - 7. Retrieved 2021/05/17.