2,2,2-trifluoro-N-(2-(1-(4-fluorophenyl)-1-hydroxyprop-2-yn-1-yl)-4-methylphenyl)acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-(2-(1-(4-fluorophenyl)-1-hydroxyprop-2-yn-1-yl)-4-methylphenyl)acetamide
CAS No.:1609487-68-4
Molecular Formula:C₁₈H₁₃F₄NO₂
Molecular Weight:351.3
Hs Code.:

Synonyms:2,2,2-trifluoro-N-(2-(1-(4-fluorophenyl)-1-hydroxyprop-2-yn-1-yl)-4-methylphenyl)acetamide

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Chemical Property of 2,2,2-trifluoro-N-(2-(1-(4-fluorophenyl)-1-hydroxyprop-2-yn-1-yl)-4-methylphenyl)acetamide

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Technology Process of 2,2,2-trifluoro-N-(2-(1-(4-fluorophenyl)-1-hydroxyprop-2-yn-1-yl)-4-methylphenyl)acetamide

There total 2 articles about 2,2,2-trifluoro-N-(2-(1-(4-fluorophenyl)-1-hydroxyprop-2-yn-1-yl)-4-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: C₁₆H₁₁F₄NO₂

: 4301-14-8
acetylenemagnesium bromide

: 1609487-68-4
2,2,2-trifluoro-N-(2-(1-(4-fluorophenyl)-1-hydroxyprop-2-yn-1-yl)-4-methylphenyl)acetamide

Guidance literature:: In tetrahydrofuran; for 3h; Reflux;
DOI:10.1021/ol501048x

Reference yield:

: 91713-56-3
2-amino-5-methylphenyl 4-fluorophenyl ketone

: 1609487-68-4
2,2,2-trifluoro-N-(2-(1-(4-fluorophenyl)-1-hydroxyprop-2-yn-1-yl)-4-methylphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.17 h / -78 - 20 °C

2: tetrahydrofuran / 3 h / Reflux

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol501048x