Methanone, (2-amino-5-methylphenyl)(4-fluorophenyl)-

Base Information

Chemical Name:Methanone, (2-amino-5-methylphenyl)(4-fluorophenyl)-
CAS No.:91713-56-3
Molecular Formula:C14H12FNO
Molecular Weight:229.254
Hs Code.:
DSSTox Substance ID:DTXSID20450129
Wikidata:Q82269712

Synonyms:Methanone, (2-amino-5-methylphenyl)(4-fluorophenyl)-;91713-56-3;(2-Amino-5-methylphenyl)(4-fluorophenyl)methanone;SCHEMBL5382884;DTXSID20450129;WHIAIKVQXGMCTR-UHFFFAOYSA-N;AKOS014793698

Suppliers and Price of Methanone, (2-amino-5-methylphenyl)(4-fluorophenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanone, (2-amino-5-methylphenyl)(4-fluorophenyl)-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:229.090292168
Heavy Atom Count:17
Complexity:273

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)N)C(=O)C2=CC=C(C=C2)F

Technology Process of Methanone, (2-amino-5-methylphenyl)(4-fluorophenyl)-

There total 3 articles about Methanone, (2-amino-5-methylphenyl)(4-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 399-05-3
4-fluoro-N-(4-methylphenyl)benzamide

: 403-43-0
4-fluorobenzoyl chloride

: (5-amino-2-methylphenyl)(4-fluorophenyl)methanone

: 91713-56-3
2-amino-5-methylphenyl 4-fluorophenyl ketone

Guidance literature:: 4-fluoro-N-(4-methylphenyl)benzamide; 4-fluorobenzoyl chloride; With copper(II) bis(trifluoromethanesulfonate); In neat (no solvent); at 150 ℃; for 2h; Green chemistry;

With sulfuric acid; water; acetic acid; at 150 ℃; for 1h; regioselective reaction; Green chemistry;
DOI:10.1080/00397911.2016.1148164

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 106-49-0,12221-03-3
p-toluidine

: 91713-56-3
2-amino-5-methylphenyl 4-fluorophenyl ketone

Guidance literature:: 4-fluorobenzonitrile; p-toluidine; With aluminium trichloride; boron trichloride; In toluene; xylene; for 12h; Heating;

With hydrogenchloride; for 2h; Heating;
DOI:10.1021/jm0301787

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: (5-amino-2-methylphenyl)(4-fluorophenyl)methanone

: 91713-56-3
2-amino-5-methylphenyl 4-fluorophenyl ketone

Guidance literature:: Multi-step reaction with 2 steps

1.1: neat (no solvent) / 0.08 h / 100 °C

2.1: copper(II) bis(trifluoromethanesulfonate) / neat (no solvent) / 2 h / 150 °C / Green chemistry

2.2: 1 h / 150 °C / Green chemistry

With copper(II) bis(trifluoromethanesulfonate); In neat (no solvent); 2.1: |Friedel-Crafts Acylation;
DOI:10.1080/00397911.2016.1148164