ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Base Information

Chemical Name:ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
CAS No.:59469-49-7
Molecular Formula:C₂₁H₁₇ClFN₃O₂
Molecular Weight:397.836
Hs Code.:
European Community (EC) Number:620-286-6
DSSTox Substance ID:DTXSID801118767

Synonyms:DTXSID801118767;59469-49-7;ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Suppliers and Price of ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:397.0993326
Heavy Atom Count:28
Complexity:619

Purity/Quality:: 99.9% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C2CN=C(C3=C(N2C(=N1)C)C=CC(=C3)Cl)C4=CC=CC=C4F

Technology Process of ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

There total 8 articles about ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 77132-93-5
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester 5-oxide

: 59469-49-7
Ro 21-6476

Guidance literature:: With phosphorus trichloride; In dichloromethane; for 48h; Ambient temperature;
DOI:10.1002/jhet.5570230509

Reference yield:

: 77132-80-0
7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-ylideneacetic acid ethyl ester 4-oxide

: 59469-49-7
Ro 21-6476

Guidance literature:: Multi-step reaction with 3 steps

1: PCl₃ / CH₂Cl₂ / 3 h / Ambient temperature

2: 85 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

With acetic acid; sodium nitrite; phosphorus trichloride; In dichloromethane;
DOI:10.1002/jhet.5570230509

Reference yield:

: 60656-74-8
6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide

: 59469-49-7
Ro 21-6476

Guidance literature:: Multi-step reaction with 4 steps

1: 1) lithium diisopropylamide / 1) hexane, tetrahydrofuran, -50 to -45 deg C 2) warming to room temperature, 2 h

2: PCl₃ / CH₂Cl₂ / 3 h / Ambient temperature

3: 85 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

With acetic acid; lithium diisopropyl amide; sodium nitrite; phosphorus trichloride; In dichloromethane;
DOI:10.1002/jhet.5570230509