Phenyl-[3-((S)-toluene-4-sulfinyl)-4H-pyridin-1-yl]-methanone

Base Information

• Chemical Name: Phenyl-[3-((S)-toluene-4-sulfinyl)-4H-pyridin-1-yl]-methanone
• CAS No.: 187862-56-2
• Molecular Formula: C₁₉H₁₇NO₂S
• Molecular Weight: 323.415
• Mol file: 187862-56-2.mol

Synonyms:Phenyl-[3-((S)-toluene-4-sulfinyl)-4H-pyridin-1-yl]-methanone

Chemical Property of Phenyl-[3-((S)-toluene-4-sulfinyl)-4H-pyridin-1-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenyl-[3-((S)-toluene-4-sulfinyl)-4H-pyridin-1-yl]-methanone

There total 1 articles about Phenyl-[3-((S)-toluene-4-sulfinyl)-4H-pyridin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

benzoyl chloride (98-88-4) + (SS)-3-(p-tolylsulfinyl)pyridine (108771-11-5) → Phenyl-[3-((S)-toluene-4-sulfinyl)-2H-pyridin-1-yl]-methanone + Phenyl-[3-((S)-toluene-4-sulfinyl)-4H-pyridin-1-yl]-methanone (187862-56-2) + Phenyl-[5-((S)-toluene-4-sulfinyl)-2H-pyridin-1-yl]-methanone

Guidance literature:

With sodium cyanoborohydride; In isopropyl alcohol; at 0 ℃; for 90h;

DOI:10.3987/com-96-s55

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + Phenyl-[3-((S)-toluene-4-sulfinyl)-4H-pyridin-1-yl]-methanone (187862-56-2) → 3-((S)-Toluene-4-sulfinyl)-4H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:

With methyllithium; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.3987/com-96-s55

Reference yield: 91.0%

benzyl bromide (100-39-0) + Phenyl-[3-((S)-toluene-4-sulfinyl)-4H-pyridin-1-yl]-methanone (187862-56-2) → (SS)-1-benzyl-3-(p-tolylsulfinyl)-1,4-dihydropyridine (119090-25-4)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; methyllithium; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.3987/com-96-s55

upstream raw materials:

benzoyl chloride

(S_S)-3-(p-tolylsulfinyl)pyridine

Downstream raw materials:

(S_S)-1-benzyl-3-(p-tolylsulfinyl)-1,4-dihydropyridine

1-Propyl-3-((S)-toluene-4-sulfinyl)-1,4-dihydro-pyridine