3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-1-[5-(2-hydroxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-butan-2-ol

Base Information

Chemical Name:3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-1-[5-(2-hydroxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-butan-2-ol
CAS No.:919608-49-4
Molecular Formula:C₃₁H₅₀O₆
Molecular Weight:518.734
Hs Code.:

Synonyms:3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-1-[5-(2-hydroxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-butan-2-ol

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Chemical Property of 3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-1-[5-(2-hydroxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-butan-2-ol

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Technology Process of 3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-1-[5-(2-hydroxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-butan-2-ol

There total 25 articles about 3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-1-[5-(2-hydroxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2-{5-[3-(1-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-ethyl)-oxiranyl]-tetrahydro-furan-2-yl}-propoxy)-tert-butyl-diphenyl-silane

: 919608-49-4
3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-1-[5-(2-hydroxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-butan-2-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 12h;
DOI:10.1002/anie.200602860

Reference yield:

: 919608-28-9
3-[5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-2-methyl-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

: 919608-49-4
3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-1-[5-(2-hydroxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-butan-2-ol

Guidance literature:: Multi-step reaction with 9 steps

1: lithium borohydride / diethyl ether; tetrahydrofuran / 0 - 20 °C

2: 3.59 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

3: 98 percent / TEA / CH₂Cl₂ / 0 - 20 °C

4: 84 percent / CSA; methanol / 2 h / 20 °C

5: 80 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

6: 89 percent / SO₃*pyridine; TEA; DMSO / CH₂Cl₂ / 0.5 h / 20 °C

7: 557 mg / tetrahydrofuran; hexane / -78 - 20 °C

8: 85 percent / m-CPBA / CH₂Cl₂ / 3 h

9: lithium aluminum hydride / diethyl ether / 12 h

With 1H-imidazole; methanol; lithium aluminium tetrahydride; lithium borohydride; pyridine-SO₃ complex; TEA; camphor-10-sulfonic acid; sodium hexamethyldisilazane; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 5: Williamson ether synthesis / 7: Wittig olefination;
DOI:10.1016/j.tet.2007.07.005

Reference yield:

: 919608-12-1
1-(tert-butyl-diphenyl-silanyloxy)-5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentan-3-ol

: 919608-49-4
3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-1-[5-(2-hydroxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-butan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / TEA / CH₂Cl₂ / 0 - 20 °C

2: 84 percent / CSA; methanol / 2 h / 20 °C

3: 80 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

4: 89 percent / SO₃*pyridine; TEA; DMSO / CH₂Cl₂ / 0.5 h / 20 °C

5: 557 mg / tetrahydrofuran; hexane / -78 - 20 °C

6: 85 percent / m-CPBA / CH₂Cl₂ / 3 h

7: lithium aluminum hydride / diethyl ether / 12 h

With methanol; lithium aluminium tetrahydride; pyridine-SO₃ complex; TEA; camphor-10-sulfonic acid; sodium hexamethyldisilazane; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 3: Williamson ether synthesis / 5: Wittig olefination;
DOI:10.1016/j.tet.2007.07.005