Pantoprazole Impurity 11

Base Information

• Chemical Name: Pantoprazole Impurity 11
• CAS No.: 172282-50-7
• Molecular Formula: C₇H₈F₂N₂O
• Molecular Weight: 174.15
• Hs Code.: 2922290090
• Mol file: 172282-50-7.mol

Synonyms:4-(difluoromethoxy)benzene-1,2-diamine

Chemical Property of Pantoprazole Impurity 11

Chemical Property:

• Boiling Point: 294.7±35.0 °C(Predicted)
• PKA: 3.71±0.10(Predicted)
• Density: 1.347±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Benzene (Slightly), Chloroform (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

4-(Difluoromethoxy)benzene-1,2-diamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Difluoromethoxy-1,2-phenylendiamine is used in preparation of benzimidazole derivatives as TRPC6 inhibitors

Technology Process of Pantoprazole Impurity 11

There total 7 articles about Pantoprazole Impurity 11 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-chloro-4-(difluoromethoxy)aniline (1247745-21-6) → 4-(difluoromethoxy)benzene-1,2-diamine (172282-50-7)

Guidance literature:

With ammonium hydroxide; copper(l) chloride; at 20 ℃; for 6h; Autoclave;

Reference yield:

4-(difluoromethoxy)-1,2-dinitrobenzene → 4-(difluoromethoxy)benzene-1,2-diamine (172282-50-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;

DOI:10.1002/adsc.201800824

Reference yield:

N-[4-(difluoromethoxy)phenyl]-acetamide (22236-11-9) → 4-(difluoromethoxy)benzene-1,2-diamine (172282-50-7)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid; sulfuric acid / 2 h / 20 - 25 °C

2: methanol / 3 h / Reflux

3: hydrazine hydrate / 4 h / Reflux

With sulfuric acid; nitric acid; hydrazine hydrate; In methanol;

DOI:10.14233/ajchem.2013.14818

upstream raw materials:

4-acetaminophenol

N-[4-(difluoromethoxy)phenyl]-acetamide

N-[(4-difluoromethoxy-2-nitro)phenyl]-acetamide

4-difluoromethoxy-2-nitroaniline

Downstream raw materials:

SKA-47

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

pantoprazole sulfide