22236-11-9

Basic information

• Product Name: 4'-(Difluoromethoxy)acetanilide
• Synonyms: N-(4-DIFLUOROMETHOXYPHENYL)ACETAMIDE;4-DIFLUOROMETHOXY-ACETANILID;4'-(DIFLUOROMETHOXY)ACETANILIDE;4-DIFLUOROMETHOXY-ACETANILIDE;4-DIFLUOROMETHOXY-ACETANILID(N-(4-DIFLUOROMETHOXYPHENYL)ACETAMIDE);4'-(Difluoromethoxy);N-[4-(Difluoromethoxy)phenyl]acetamide, 4-Acetamido-alpha,alpha-difluoroanisole
• CAS NO: 22236-11-9
• Molecular Formula: C₉H₉F₂NO₂
• Molecular Weight: 201.17
• Mol File: 22236-11-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 338.579 °C at 760 mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.275 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.30±0.70(Predicted)
• CAS DataBase Reference: 4'-(Difluoromethoxy)acetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(Difluoromethoxy)acetanilide(22236-11-9)
• EPA Substance Registry System: 4'-(Difluoromethoxy)acetanilide(22236-11-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 22236-11-9(Hazardous Substances Data)

Usage

Uses

4''-(Difluoromethoxy)acetanilide

Upstream product

• 22236-10-8 4-difluoromethoxyaniline 
• 108-24-7 acetic anhydride 
• 75-45-6 Chlorodifluoromethane 
• 103-90-2 4-acetaminophenol 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 

Downstream Products

• 97963-62-7 SKA-47 
• 97963-76-3 4-difluoromethoxy-2-nitroaniline 
• 172282-50-7 4-(difluoromethoxy)benzene-1,2-diamine 
• 97963-75-2 N-[(4-difluoromethoxy-2-nitro)phenyl]-acetamide 

Relevant articles and documents

Difluoromethylation of Phenols and Thiophenols with the S-(Difluo-romethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study

A facile and practical approach for the difluoromethylation of phenols and thiophenols was described. Making use of the recently developed bench-stable S-(difluoromethyl)sulfonium salt as the difluorocarbene precursor, a wide variety of diversely functionalized phenols and thiophenols were readily converted to their corresponding aryl difluoromethyl ethers in good to excellent yields in the presence of lithium hydroxide. Chemoselectivity of various O,S-nucleophiles toward difluorocarbene was systematically studied, suggesting the reactivity order ArS- > RS-, ArO- > ROH > RO-, ArSH, ArOH, RSH.

Synthesis of gem-difluorocyclopropa(e)nes and O-, S-, N-, and P-difluoromethylated compounds with TMSCF2Br

Two-in-one: Me3SiCF2Br is an efficient difluorocarbene source and is compatible with both neutral and aqueous basic conditions. Bromide-ion-initiated [2+1] cycloaddition with alkenes/alkynes and hydroxide ion promoted α-addition with (thio)phenols, (thio)alcohols, sulfinates, heterocyclic amines, and H-phosphine oxides give the corresponding gem-difluorinated compounds with broad functional-group tolerance. Copyright

Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.