22236-11-9

Basic information

• Product Name: 4'-(Difluoromethoxy)acetanilide
• Synonyms: N-(4-DIFLUOROMETHOXYPHENYL)ACETAMIDE;4-DIFLUOROMETHOXY-ACETANILID;4'-(DIFLUOROMETHOXY)ACETANILIDE;4-DIFLUOROMETHOXY-ACETANILIDE;4-DIFLUOROMETHOXY-ACETANILID(N-(4-DIFLUOROMETHOXYPHENYL)ACETAMIDE);4'-(Difluoromethoxy);N-[4-(Difluoromethoxy)phenyl]acetamide, 4-Acetamido-alpha,alpha-difluoroanisole
• CAS NO: 22236-11-9
• Molecular Formula: C₉H₉F₂NO₂
• Molecular Weight: 201.17
• Mol File: 22236-11-9.mol

Chemical Properties

• Boiling Point: 338.579 °C at 760 mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.275 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.30±0.70(Predicted)
• CAS DataBase Reference: 4'-(Difluoromethoxy)acetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(Difluoromethoxy)acetanilide(22236-11-9)
• EPA Substance Registry System: 4'-(Difluoromethoxy)acetanilide(22236-11-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 22236-11-9(Hazardous Substances Data)

Usage

Uses

4''-(Difluoromethoxy)acetanilide

Upstream product

• 22236-10-8 4-difluoromethoxyaniline 
• 108-24-7 acetic anhydride 
• 103-90-2 4-acetaminophenol 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 75-45-6 Chlorodifluoromethane 

Downstream Products

• 97963-62-7 SKA-47 
• 97963-76-3 4-difluoromethoxy-2-nitroaniline 
• 172282-50-7 4-(difluoromethoxy)benzene-1,2-diamine 
• 97963-75-2 N-[(4-difluoromethoxy-2-nitro)phenyl]-acetamide 

Relevant articles and documents

Difluoromethylation of Phenols and Thiophenols with the S-(Difluo-romethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study

A facile and practical approach for the difluoromethylation of phenols and thiophenols was described. Making use of the recently developed bench-stable S-(difluoromethyl)sulfonium salt as the difluorocarbene precursor, a wide variety of diversely functionalized phenols and thiophenols were readily converted to their corresponding aryl difluoromethyl ethers in good to excellent yields in the presence of lithium hydroxide. Chemoselectivity of various O,S-nucleophiles toward difluorocarbene was systematically studied, suggesting the reactivity order ArS- > RS-, ArO- > ROH > RO-, ArSH, ArOH, RSH.

SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES

The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone- depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

Synthesis of gem-difluorocyclopropa(e)nes and O-, S-, N-, and P-difluoromethylated compounds with TMSCF2Br

Two-in-one: Me3SiCF2Br is an efficient difluorocarbene source and is compatible with both neutral and aqueous basic conditions. Bromide-ion-initiated [2+1] cycloaddition with alkenes/alkynes and hydroxide ion promoted α-addition with (thio)phenols, (thio)alcohols, sulfinates, heterocyclic amines, and H-phosphine oxides give the corresponding gem-difluorinated compounds with broad functional-group tolerance. Copyright

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1H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF

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Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof

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INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.