1-Acetyl-alpha-(5-oxo-2-phenyl-2-oxazolin-4-ylidene)skatole

Base Information

Chemical Name:1-Acetyl-alpha-(5-oxo-2-phenyl-2-oxazolin-4-ylidene)skatole
CAS No.:133363-40-3
Molecular Formula:C₂₀H₁₄N₂O₃
Molecular Weight:330.343
Hs Code.:
NSC Number:202094
UNII:6W3FY5L8BR
ChEMBL ID:CHEMBL4558046

Synonyms:1-Acetyl-alpha-(5-oxo-2-phenyl-2-oxazolin-4-ylidene)skatole;NSC202094;NSC 202094;77362-24-4;NSC-202094;(Z)-4-((1-acetyl-1H-indol-3-yl)methylene)-2-phenyloxazol-5(4H)-one;6W3FY5L8BR;CHEMBL4558046;AKOS024356399;SR-01000207505;SR-01000207505-1;(4Z)-4-[(1-acetylindol-3-yl)methylene]-2-phenyl-oxazol-5-one;4-[(1-Acetyl-1H-indol-3-yl)methylene]-2-phenyl-5(4H)-oxazolone;1H-Indole, 1-acetyl-3-[(5-oxo-2-phenyl-4(5H)-oxazolylidene)methyl]-;4-[(1-acetyl-1H-indol-3-yl)methylene]-2-phenyl-1,3-oxazol-5(4H)-one;4-[(1-acetylindol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5-one, (4Z)-;5(4H)-Oxazolone, 4-[(1-acetyl-1H-indol-3-yl)methylene]-2-phenyl-;1H-Indole, 1-acetyl-3-[(5-oxo-2-phenyl-4(5H)-oxazolylidene)methyl]-, (Z)-;133363-40-3

Suppliers and Price of 1-Acetyl-alpha-(5-oxo-2-phenyl-2-oxazolin-4-ylidene)skatole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of 1-Acetyl-alpha-(5-oxo-2-phenyl-2-oxazolin-4-ylidene)skatole

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:330.10044231
Heavy Atom Count:25
Complexity:618

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)N1C=C(C2=CC=CC=C21)C=C3C(=O)OC(=N3)C4=CC=CC=C4
Isomeric SMILES:CC(=O)N1C=C(C2=CC=CC=C21)/C=C\3/C(=O)OC(=N3)C4=CC=CC=C4

Technology Process of 1-Acetyl-alpha-(5-oxo-2-phenyl-2-oxazolin-4-ylidene)skatole

There total 9 articles about 1-Acetyl-alpha-(5-oxo-2-phenyl-2-oxazolin-4-ylidene)skatole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 42136-84-5,102913-26-8
4-(Z)-(4-(1H-indol-3-yl)methylene)-2-phenyloxazol-4(4H)-one

: 108-24-7
acetic anhydride

: 133363-40-3
4-<3-(1-acetylindolyl)>methylene-2-phenyl-oxazolin-5-one

Guidance literature:: With sodium acetate; for 1.5h; Heating;

Reference yield: 67.0%

: 495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2
Hippuric Acid

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 108-24-7
acetic anhydride

: 133363-40-3
4-<3-(1-acetylindolyl)>methylene-2-phenyl-oxazolin-5-one

Guidance literature:: With sodium acetate; for 2h; Heating;

Reference yield:

: 98-88-4
benzoyl chloride

: 133363-40-3
4-<3-(1-acetylindolyl)>methylene-2-phenyl-oxazolin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

2: sodium acetate / 4 h / Reflux

With sodium acetate; sodium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1002/ardp.201700299