1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane

Base Information

Chemical Name:1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane
CAS No.:244262-58-6
Molecular Formula:C₃₆H₃₁Cl₃O₁₂
Molecular Weight:761.994
Hs Code.:

Synonyms:1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane

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Chemical Property of 1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane

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Technology Process of 1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane

There total 7 articles about 1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 97-97-2
chloroacetaldehyde dimethyl acetal

: 244262-55-3
1,1-bis[3-chloro-4',6-dihydroxy-5,5'-dimethoxycarbonyldiphenyl]methane

: 244262-58-6
1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane

Guidance literature:: With sulfuric acid; acetic acid; at 0 - 20 ℃;
DOI:10.1021/jo990177f

Reference yield:

: 89-55-4
5-bromosalicyclic acid

: 244262-58-6
1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / TFA / 16 h / 90 °C / Acid hydrolysis

2: 90 percent / NaOH; NaBH₄ / ethanol; H₂O / 4 h / 0 °C

3: conc. H₂SO₄ / methanol / 12 h / 0 - 20 °C

4: 32 percent / H₂SO₄ / Heating

5: 77 percent / NaOH; Zn dust / Acid hydrolysis

6: 65 percent / H₂SO₄ / 36 h / 80 °C

7: 30 percent / H₂SO₄; AcOH / 0 - 20 °C

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; acetic acid; trifluoroacetic acid; zinc; In methanol; ethanol; water; 1: Formylation / 2: Reduction / 3: Substitution / 4: Esterification / 5: Reduction / 6: Esterification / 7: Substitution;
DOI:10.1021/jo990177f

Reference yield:

: 134948-41-7
5-bromo-3-formyl-2-hydroxybenzoic acid

: 244262-58-6
1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / NaOH; NaBH₄ / ethanol; H₂O / 4 h / 0 °C

2: conc. H₂SO₄ / methanol / 12 h / 0 - 20 °C

3: 32 percent / H₂SO₄ / Heating

4: 77 percent / NaOH; Zn dust / Acid hydrolysis

5: 65 percent / H₂SO₄ / 36 h / 80 °C

6: 30 percent / H₂SO₄; AcOH / 0 - 20 °C

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; acetic acid; zinc; In methanol; ethanol; water; 1: Reduction / 2: Substitution / 3: Esterification / 4: Reduction / 5: Esterification / 6: Substitution;
DOI:10.1021/jo990177f