Technology Process of 3-(2-(benzyloxy)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)phenethyl)-5-(1-(1-methylethoxy)phenyl-4-yl)-5-methylimidazolidine-2,4-dione
There total 9 articles about 3-(2-(benzyloxy)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)phenethyl)-5-(1-(1-methylethoxy)phenyl-4-yl)-5-methylimidazolidine-2,4-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: borane-THF / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
4.1: hydrogenchloride / ethyl acetate / 1 h / 0 - 20 °C
With
hydrogenchloride; borane-THF; carbon tetrabromide; potassium carbonate; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.05.048
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C
3.1: acetic acid; iron / water / 4 h / 20 °C
4.1: potassium iodide; toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 0 - 20 °C
5.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 80 °C / Microwave irradiation
6.1: borane-THF / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
6.2: 0 - 20 °C / Inert atmosphere
7.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C
8.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
9.1: hydrogenchloride / ethyl acetate / 1 h / 0 - 20 °C
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); borane-THF; carbon tetrabromide; iron; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triphenylphosphine; potassium iodide; sodium nitrite;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
5.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2016.05.048
