3-(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propanal

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Chemical Name:3-(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propanal
CAS No.:1351815-49-0
Molecular Formula:C₃₅H₃₃NO₄
Molecular Weight:531.651
Hs Code.:

Synonyms:3-(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propanal

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Chemical Property of 3-(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propanal

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Technology Process of 3-(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propanal

There total 9 articles about 3-(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912545-08-5
2,4-bis-benzyloxy-5-isopropenyl-benzoic acid methyl ester

: 1351815-49-0
3-(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propanal

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; methanol / 20 h / 75 °C

1.2: 0.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 100 h / 20 °C

3.1: Wilkinson's catalyst / ethyl acetate / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 1.5 h

With methanol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dmap; Wilkinson's catalyst; In dichloromethane; ethyl acetate;

Reference yield:

: 1351815-48-9
[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][5-(3-hydroxypropyl)-1,3-dihydro-2H-isoindol-2-yl]methanone

: 1351815-49-0
3-(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propanal

Guidance literature:: With Dess-Martin periodane; In dichloromethane; for 1.5h;

Reference yield:

: 100-39-0
benzyl bromide

: 1351815-49-0
3-(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)propanal

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 42 h / 75 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

2.2: 0.5 h

3.1: potassium hydroxide; methanol / 20 h / 75 °C

3.2: 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 100 h / 20 °C

5.1: Wilkinson's catalyst / ethyl acetate / 20 °C

6.1: Dess-Martin periodane / dichloromethane / 1.5 h

With methanol; potassium tert-butylate; potassium carbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dmap; Wilkinson's catalyst; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;