tert-Butyl 3-(4-(dimethylamino)-4-phenylpiperidin-1-yl)propyl(methyl)-carbamate

Base Information

Chemical Name:tert-Butyl 3-(4-(dimethylamino)-4-phenylpiperidin-1-yl)propyl(methyl)-carbamate
CAS No.:1181285-69-7
Molecular Formula:C₂₂H₃₇N₃O₂
Molecular Weight:375.555
Hs Code.:

Synonyms:tert-Butyl 3-(4-(dimethylamino)-4-phenylpiperidin-1-yl)propyl(methyl)-carbamate

Suppliers and Price of tert-Butyl 3-(4-(dimethylamino)-4-phenylpiperidin-1-yl)propyl(methyl)-carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-Butyl 3-(4-(dimethylamino)-4-phenylpiperidin-1-yl)propyl(methyl)-carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-Butyl 3-(4-(dimethylamino)-4-phenylpiperidin-1-yl)propyl(methyl)-carbamate

There total 10 articles about tert-Butyl 3-(4-(dimethylamino)-4-phenylpiperidin-1-yl)propyl(methyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: N,N-dimethyl-4-phenylpiperidin-4-amine dihydrochloride

: 273757-11-2
tert-butyl methyl(3-oxopropyl)carbamate

: 1181285-69-7
tert-Butyl 3-(4-(dimethylamino)-4-phenylpiperidin-1-yl)propyl(methyl)-carbamate

Guidance literature:: N,N-dimethyl-4-phenylpiperidin-4-amine dihydrochloride; tert-butyl methyl(3-oxopropyl)carbamate; In methanol; at 0 ℃; for 0.25h;

With methanol; sodium cyanoborohydride; at 20 ℃;

With acetic acid; In methanol; at 20 ℃; for 13h; pH=5 - 6;

Reference yield: 60.0%

: 4-butyl-N,N-dimethylpiperidine-4-amine bishydrochloride

: 273757-11-2
tert-butyl methyl(3-oxopropyl)carbamate

: 1181285-69-7
tert-Butyl 3-(4-(dimethylamino)-4-phenylpiperidin-1-yl)propyl(methyl)-carbamate

Guidance literature:: 4-butyl-N,N-dimethylpiperidine-4-amine bishydrochloride; tert-butyl methyl(3-oxopropyl)carbamate; In methanol; at 0 ℃; for 0.25h;

With sodium cyanoborohydride; In methanol; at 0 - 20 ℃;

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1181285-69-7
tert-Butyl 3-(4-(dimethylamino)-4-phenylpiperidin-1-yl)propyl(methyl)-carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / dichloromethane / 0.17 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0 - 10 °C

2.2: 10 - 20 °C

3.1: water; acetic acid / tetrahydrofuran / 0 - 20 °C

4.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate / dichloromethane; water / 0.75 h / 0 °C

5.1: methanol / 0.25 h / 0 °C

5.2: 0 - 20 °C

With 1H-imidazole; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; sodium hydride; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water;