tert-butyl {3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}carbamate

Base Information

Chemical Name:tert-butyl {3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}carbamate
CAS No.:1346570-82-8
Molecular Formula:C₃₀H₂₉ClN₂O₃
Molecular Weight:501.025
Hs Code.:

Synonyms:tert-butyl {3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}carbamate

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Chemical Property of tert-butyl {3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}carbamate

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Technology Process of tert-butyl {3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}carbamate

There total 5 articles about tert-butyl {3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1346570-80-6
3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-amine

: 1346570-82-8
tert-butyl {3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}carbamate

Guidance literature:: With triethylamine; In water; acetonitrile; at 22 - 26 ℃; for 6h;

Reference yield:

: C₂₇H₂₂ClNO₃

: 1346570-82-8
tert-butyl {3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 3 h / -40 - -30 °C

1.2: 0.5 h

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0 °C

3.1: sodium azide / N,N-dimethyl-formamide / 60 °C

4.1: triphenylphosphine / tetrahydrofuran / 3 h / 22 - 26 °C

5.1: triethylamine / acetonitrile; water / 6 h / 22 - 26 °C

With sodium azide; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1346570-28-2
2-({4-[3-chloro-1-(4-chlorophenyl)prop-1-en-2-yl]phenoxy}methyl)quinoline

: 1346570-82-8
tert-butyl {3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 60 °C

2: triphenylphosphine / tetrahydrofuran / 3 h / 22 - 26 °C

3: triethylamine / acetonitrile; water / 6 h / 22 - 26 °C

With sodium azide; triethylamine; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;