3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-amine

Base Information

Chemical Name:3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-amine
CAS No.:1346570-80-6
Molecular Formula:C₂₅H₂₁ClN₂O
Molecular Weight:400.908
Hs Code.:

Synonyms:3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-amine

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Chemical Property of 3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-amine

Chemical Property:

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Technology Process of 3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-amine

There total 4 articles about 3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346570-79-3
2-({4-[3-azido-1-(4-chlorophenyl)prop-1-en-2-yl]phenoxy}methyl)quinoline

: 1346570-80-6
3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-amine

Guidance literature:: 2-({4-[3-azido-1-(4-chlorophenyl)prop-1-en-2-yl]phenoxy}methyl)quinoline; With triphenylphosphine; In tetrahydrofuran; at 22 - 26 ℃; for 3h;

With water; In tetrahydrofuran;

Reference yield:

: C₂₇H₂₂ClNO₃

: 1346570-80-6
3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 3 h / -40 - -30 °C

1.2: 0.5 h

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0 °C

3.1: sodium azide / N,N-dimethyl-formamide / 60 °C

4.1: triphenylphosphine / tetrahydrofuran / 3 h / 22 - 26 °C

With sodium azide; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1346570-27-1
3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-ol

: 1346570-80-6
3-(4-chlorophenyl)-2-[4-(quinolin-2-ylmethoxy)phenyl]prop-2-en-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; methanesulfonyl chloride / dichloromethane / 0 °C

2: sodium azide / N,N-dimethyl-formamide / 60 °C

3: triphenylphosphine / tetrahydrofuran / 3 h / 22 - 26 °C

With sodium azide; methanesulfonyl chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;