(11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Base Information

Chemical Name:(11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate
CAS No.:1430738-48-9
Molecular Formula:C₅₄H₇₆FN₅O₁₀Si₂
Molecular Weight:1030.39
Hs Code.:

(11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Synonyms:(11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

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Chemical Property of (11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

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Technology Process of (11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

There total 22 articles about (11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1430738-47-8
(11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 2-(4-fluorophenyl)-11-hydroxy-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

: 133732-91-9
tert-butyldimethylsilyl triflate

: 1430738-48-9
(11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; for 1.16h;

Reference yield:

: 623-04-1
4-aminobenzenemethanol

: 1430738-48-9
(11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / tetrahydrofuran / 72 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 4 h / 40 °C

3.1: acetic acid / water; tetrahydrofuran-d8 / 16 h / 20 °C

4.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: 2,6-dimethylpyridine / dichloromethane / 1.16 h / 0 - 20 °C

With 2,6-dimethylpyridine; oxalyl dichloride; acetic acid; dimethyl sulfoxide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In tetrahydrofuran; tetrahydrofuran-d8; dichloromethane; water;

Reference yield:

: 1343407-91-9
allyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1- oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

: 1430738-48-9
(11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 4 h / 40 °C

2.1: acetic acid / water; tetrahydrofuran-d8 / 16 h / 20 °C

3.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 1.16 h / 0 - 20 °C

With 2,6-dimethylpyridine; oxalyl dichloride; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; tetrahydrofuran-d8; dichloromethane; water;