(S)-3,5-dichloro-4-(2-(2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide 2,2,2-trifluoroacetate

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide 2,2,2-trifluoroacetate
CAS No.:1428847-41-9
Molecular Formula:C₃₉H₄₆Cl₂F₂N₄O₁₀S
Molecular Weight:871.784
Hs Code.:

(S)-3,5-dichloro-4-(2-(2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide 2,2,2-trifluoroacetate

Synonyms:(S)-3,5-dichloro-4-(2-(2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide 2,2,2-trifluoroacetate

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Chemical Property of (S)-3,5-dichloro-4-(2-(2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide 2,2,2-trifluoroacetate

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Technology Process of (S)-3,5-dichloro-4-(2-(2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide 2,2,2-trifluoroacetate

There total 7 articles about (S)-3,5-dichloro-4-(2-(2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.2%

: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide

: 1428847-48-6
2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoyloxy)acetic acid

: 1428847-41-9
(S)-3,5-dichloro-4-(2-(2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide 2,2,2-trifluoroacetate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 1239278-74-0
3-cyclopropylmethoxy-4-(N-tert-butoxycarbonyl-N-methanesulfonyl)aminobenzoic acid methyl ester

: 1428847-41-9
(S)-3,5-dichloro-4-(2-(2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 72 h / 20 °C

2: carbon tetrabromide / dichloromethane / 2 h / 20 °C

3: potassium carbonate / acetonitrile / 3 h / 130 °C / Microwave irradiation

4: lithium hydroxide / tetrahydrofuran / 6 h / 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h / 20 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 1034.32 Torr

7: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With hydrogenchloride; dmap; carbon tetrabromide; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;

Reference yield:

: 1239278-73-9
3-cyclopropylmethoxy-4-methanesulfonylaminobenzoic acid methyl ester

: 1428847-41-9
(S)-3,5-dichloro-4-(2-(2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: carbon tetrabromide / dichloromethane / 2 h / 20 °C

2: potassium carbonate / acetonitrile / 3 h / 130 °C / Microwave irradiation

3: lithium hydroxide / tetrahydrofuran / 6 h / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 1034.32 Torr

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With dmap; carbon tetrabromide; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;