N-{3-[4-(acetylamino)-2,6-dichlorobenzoyl]-1H-pyrrolo[2,3-c]pyridin-7-yl}cyclopropanecarboxamide

Base Information

Chemical Name:N-{3-[4-(acetylamino)-2,6-dichlorobenzoyl]-1H-pyrrolo[2,3-c]pyridin-7-yl}cyclopropanecarboxamide
CAS No.:1415123-12-4
Molecular Formula:C₂₀H₁₆Cl₂N₄O₃
Molecular Weight:431.278
Hs Code.:

Synonyms:N-{3-[4-(acetylamino)-2,6-dichlorobenzoyl]-1H-pyrrolo[2,3-c]pyridin-7-yl}cyclopropanecarboxamide

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Chemical Property of N-{3-[4-(acetylamino)-2,6-dichlorobenzoyl]-1H-pyrrolo[2,3-c]pyridin-7-yl}cyclopropanecarboxamide

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Technology Process of N-{3-[4-(acetylamino)-2,6-dichlorobenzoyl]-1H-pyrrolo[2,3-c]pyridin-7-yl}cyclopropanecarboxamide

There total 8 articles about N-{3-[4-(acetylamino)-2,6-dichlorobenzoyl]-1H-pyrrolo[2,3-c]pyridin-7-yl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1415123-11-3
N-[3-(4-amino-2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-7-yl]cyclopropanecarboxamide

: 75-36-5
acetyl chloride

: 1415123-12-4
N-{3-[4-(acetylamino)-2,6-dichlorobenzoyl]-1H-pyrrolo[2,3-c]pyridin-7-yl}cyclopropanecarboxamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 2.5h;

Reference yield:

: 50-30-6
2,6-dichlorobenzoic acid

: 1415123-12-4
N-{3-[4-(acetylamino)-2,6-dichlorobenzoyl]-1H-pyrrolo[2,3-c]pyridin-7-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid / sulfuric acid / 1 h / 20 - 55 °C

2.1: hydrogenchloride; tin(ll) chloride / water / 1 h / 60 °C

2.2: pH 1 - 2

3.1: N-Bromosuccinimide / acetonitrile / 0.75 h / 90 °C

4.1: hydrogenchloride; sodium nitrite / water / 2 h / -10 - -5 °C

4.2: 4 h / -10 - -5 °C

5.1: thionyl chloride / dichloromethane / 5 h / Reflux

6.1: aluminum (III) chloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

7.1: sodium azide; N,N-dimethylethylenediamine / copper(l) iodide / dimethyl sulfoxide / 110 °C / Sealed vial

7.2: 20 °C

8.1: pyridine / dichloromethane / 2.5 h / 0 - 20 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; thionyl chloride; sodium azide; nitric acid; N,N-dimethylethylenediamine; tin(ll) chloride; sodium nitrite; aluminum (III) chloride; copper(l) iodide; sulfuric acid; In dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 4-bromo-2,6-dichlorobenzoyl chloride

: 1415123-12-4
N-{3-[4-(acetylamino)-2,6-dichlorobenzoyl]-1H-pyrrolo[2,3-c]pyridin-7-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: sodium azide; N,N-dimethylethylenediamine / copper(l) iodide / dimethyl sulfoxide / 110 °C / Sealed vial

2.2: 20 °C

3.1: pyridine / dichloromethane / 2.5 h / 0 - 20 °C

With pyridine; sodium azide; N,N-dimethylethylenediamine; aluminum (III) chloride; copper(l) iodide; In dichloromethane; dimethyl sulfoxide;