ethyl N-<4-amino-1-<(4-methoxybenzylidene)amino>-2(3H)-thioxoimidazo<4,5-c>pyridin-6-yl>carbamate

Base Information

• Chemical Name: ethyl N-<4-amino-1-<(4-methoxybenzylidene)amino>-2(3H)-thioxoimidazo<4,5-c>pyridin-6-yl>carbamate
• CAS No.: 123753-65-1
• Molecular Formula: C₁₇H₁₈N₆O₃S
• Molecular Weight: 386.434
• Mol file: 123753-65-1.mol

Synonyms:ethyl N-<4-amino-1-<(4-methoxybenzylidene)amino>-2(3H)-thioxoimidazo<4,5-c>pyridin-6-yl>carbamate

Chemical Property of ethyl N-<4-amino-1-<(4-methoxybenzylidene)amino>-2(3H)-thioxoimidazo<4,5-c>pyridin-6-yl>carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-<4-amino-1-<(4-methoxybenzylidene)amino>-2(3H)-thioxoimidazo<4,5-c>pyridin-6-yl>carbamate

There total 5 articles about ethyl N-<4-amino-1-<(4-methoxybenzylidene)amino>-2(3H)-thioxoimidazo<4,5-c>pyridin-6-yl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

ethyl N-<1,4-diamino-2(3H)-thioxoimidazo<4,5-c>pyridin-6-yl>carbamate (123753-62-8) + 4-methoxy-benzaldehyde (123-11-5) → ethyl N-<4-amino-1-<(4-methoxybenzylidene)amino>-2(3H)-thioxoimidazo<4,5-c>pyridin-6-yl>carbamate (123753-65-1)

Guidance literature:

With sulfuric acid; In N,N-dimethyl acetamide; at 93 ℃; for 2.5h;

DOI:10.1021/jm00164a030

Reference yield:

ethyl (6-amino-4-hydrazino-5-nitropyridin-2-yl)carbamate (109182-40-3) → ethyl N-<4-amino-1-<(4-methoxybenzylidene)amino>-2(3H)-thioxoimidazo<4,5-c>pyridin-6-yl>carbamate (123753-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Raney nickel / ethanol; H₂O / 1 h / 23 °C / 760 Torr

2: Et₃N / N,N-dimethyl-acetamide / 40 h / Ambient temperature

3: 29 percent / conc. H₂SO₄ / N,N-dimethyl-acetamide / 2.5 h / 93 °C

With sulfuric acid; hydrogen; triethylamine; nickel; In ethanol; N,N-dimethyl acetamide; water;

DOI:10.1021/jm00164a030

Reference yield:

ethyl N-<6-amino-4-(2-benzylidenehydrazino)-5-nitropyridin-2-yl>carbamate (123753-53-7) → ethyl N-<4-amino-1-<(4-methoxybenzylidene)amino>-2(3H)-thioxoimidazo<4,5-c>pyridin-6-yl>carbamate (123753-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / H₂ / Raney nickel / N,N-dimethyl-acetamide / 1.83 h / 760 Torr / Ambient temperature

2: 12 percent / Et₃N / N,N-dimethyl-acetamide / 23 h / Ambient temperature

3: 29 percent / conc. H₂SO₄ / N,N-dimethyl-acetamide / 2.5 h / 93 °C

With sulfuric acid; hydrogen; triethylamine; nickel; In N,N-dimethyl acetamide;

DOI:10.1021/jm00164a030

upstream raw materials:

ethyl N-<1,4-diamino-2(3H)-thioxoimidazo<4,5-c>pyridin-6-yl>carbamate

4-methoxy-benzaldehyde

ethyl N-(5,6-diamino-4-hydrazinopyridin-2-yl)carbamate

ethyl (6-amino-4-hydrazino-5-nitropyridin-2-yl)carbamate

Downstream raw materials:

ethyl N-<4-amino-1-<(4-methoxybenzylidene)amino>imidazo<4,5-c>pyridin-6-yl>carbamate