3-(4-methoxyphenyl)propionic acid ethanethiol ester

Base Information

• Chemical Name: 3-(4-methoxyphenyl)propionic acid ethanethiol ester
• CAS No.: 208453-06-9
• Molecular Formula: C₁₂H₁₆O₂S
• Molecular Weight: 224.324
• Mol file: 208453-06-9.mol

Synonyms:3-(4-methoxyphenyl)propionic acid ethanethiol ester

Chemical Property of 3-(4-methoxyphenyl)propionic acid ethanethiol ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-(4-methoxyphenyl)propionic acid ethanethiol ester

There total 2 articles about 3-(4-methoxyphenyl)propionic acid ethanethiol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-(4-methoxyphenyl)propanoic acid (1929-29-9) → 3-(4-methoxyphenyl)propionic acid ethanethiol ester (208453-06-9)

Guidance literature:

With mixed anhydride;

DOI:10.1246/cl.2011.959

Reference yield: 50.44%

3-(4-methoxyphenyl)propanoic acid (1929-29-9) + ethanethiol (75-08-1) → 3-(4-methoxyphenyl)propionic acid ethanethiol ester (208453-06-9)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1002/chem.201801887

Reference yield: 95.0%

(tert-butyldimethylsilyl)acetylene (86318-61-8) + 3-(4-methoxyphenyl)propionic acid ethanethiol ester (208453-06-9) → 1-(tert-butyl-dimethyl-silanyl)-5-(4-methoxy-phenyl)-pent-1-yn-3-one

Guidance literature:

With copper(l) iodide; trifuran-2-yl-phosphane; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 50 ℃; for 1h;

DOI:10.1055/s-2003-40861

upstream raw materials:

3-(4-methoxyphenyl)propanoic acid

ethanethiol

Downstream raw materials:

1-(4-methoxy-phenyl)-5-methyl-hexan-3-one

3-(4-methoxyphenyl)-1-phenylpropan-1-one

1-(4-methoxyphenyl)-5-phenylpentan-3-one

1-(4-methoxyphenyl)-3-oxo-pentane

Refernces

• 1、 Azuma, Hiroki,Okano, Kentaro,Tokuyama, Hidetoshi. "Synthesis of acylsilanes by palladium-catalyzed cross-coupling reaction of thiol esters and silylzinc chlorides". supporting information; experimental part. p. 959 - 961. Retrieved 2011/12/05.