N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodo-5-methoxybenzamide

Base Information

Chemical Name:N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodo-5-methoxybenzamide
CAS No.:1307741-72-5
Molecular Formula:C₂₂H₂₀F₆INO₅
Molecular Weight:619.299
Hs Code.:

Synonyms:N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodo-5-methoxybenzamide

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Chemical Property of N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodo-5-methoxybenzamide

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Technology Process of N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodo-5-methoxybenzamide

There total 5 articles about N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodo-5-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1307741-37-2
C₁₄H₁₅F₆NO₃

: 54413-93-3
2-iodo-5-methoxybenzoic acid

: 1307741-72-5
N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodo-5-methoxybenzamide

Guidance literature:: 2-iodo-5-methoxybenzoic acid; With Vilsmeier reagent; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

C₁₄H₁₅F₆NO₃; With triethylamine; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.03.002

Reference yield:

: 849517-65-3
4-iodobenzo[d][1,3]dioxole

: 1307741-72-5
N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodo-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 15 h / 90 °C

2.1: toluene-4-sulfonic acid / toluene / 10 h / 120 °C / Molecular sieve

3.1: Vilsmeier reagent / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: 3 h / 0 °C / Inert atmosphere

With copper(l) iodide; Vilsmeier reagent; potassium carbonate; toluene-4-sulfonic acid; L-proline; In dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1016/j.bmc.2011.03.002

Reference yield:

: 1307741-34-9
4-(butylamino)benzo[d][1,3]dioxole

: 1307741-72-5
N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodo-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / toluene / 10 h / 120 °C / Molecular sieve

2.1: Vilsmeier reagent / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.2: 3 h / 0 °C / Inert atmosphere

With Vilsmeier reagent; toluene-4-sulfonic acid; In dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.03.002