849517-65-3Relevant academic research and scientific papers
AHR INHIBITORS AND USES THEREOF
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Paragraph 0480; 0481; 0482; 0483, (2019/03/02)
The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
Synthesis and structure revision of goupiolone A: A benzotropolone natural product
Fukui, Nobuaki,Ohmori, Ken,Suzuki, Keisuke
, p. 2194 - 2217 (2013/02/22)
Goupiolone A, a benzotropolone natural product, has been synthesized by assembling a benzocyclobutene derivative and a silyl-substituted cyclopropane unit, followed by thermal ring enlargement. The synthetic sample did not correspond to the reported data. On the basis of biogenetic considerations, an alternative structure with a catechol moiety was proposed, and the synthesis established it as the correct structure.
THERAPEUTIC AGENT FOR HEPATITIS C
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Page/Page column 24, (2013/02/27)
This invention provides a therapeutic agent for hepatitis C comprising, as an active ingredient, a compound having anti-HCV activity useful in treatment of hepatitis C. The therapeutic agent for hepatitis C comprises, as an active ingredient, a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
Fused heterocyclic amido compounds as anti-hepatitis C virus agents
Aoyama, Hiroshi,Sugita, Kazuyuki,Nakamura, Masahiko,Aoyama, Atsushi,Salim, Mohammed T.A.,Okamoto, Mika,Baba, Masanori,Hashimoto, Yuichi
experimental part, p. 2675 - 2687 (2011/06/11)
We identified a fused heteroaromatic amido structure based on the phenanthridine skeleton as a superior scaffold for candidate drugs with potent anti-HCV activity. Among the compounds synthesized, a phenanthridine analogue with a 1,3-dioxolyl group (24) possessed the most potent anti-HCV activity (EC50 value: 50 nM), with acceptable cytotoxicity. The structural development and structure-activity relationships of these compounds are described.
