4-IODOBENZO[D][1,3]DIOXOLE

Base Information

• Chemical Name: 4-IODOBENZO[D][1,3]DIOXOLE
• CAS No.: 849517-65-3
• Molecular Formula: C7H5IO2
• Molecular Weight: 248.02
• Hs Code.: 2932990090
• Mol file: 849517-65-3.mol

Synonyms:1,3-Benzodioxole, 4-iodo-; 4-Iodo-1,3-benzodioxole; 4-iodobenzo[d][1,3]dioxole

Chemical Property of 4-IODOBENZO[D][1,3]DIOXOLE

Chemical Property:

• Vapor Pressure: 0.0186mmHg at 25°C
• Refractive Index: 1.66
• Boiling Point: 261.601 °C at 760 mmHg
• Flash Point: 112.012 °C
• PSA: 18.46000
• Density: 2.022 g/cm³
• LogP: 2.01990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

4-Iodobenzo[d][1,3]dioxole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-IODOBENZO[D][1,3]DIOXOLE

There total 6 articles about 4-IODOBENZO[D][1,3]DIOXOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.9%

C7H7NO2*(x)ClH → 4-iodobenzo[d][1,3]dioxole (849517-65-3)

Guidance literature:

C₇H₇NO₂*(x)ClH; With hydrogenchloride; sodium nitrite; In water; acetone; at 0 ℃; for 0.5h;

With potassium iodide; In water; acetone; at 0 - 80 ℃; for 12h;

Reference yield: 76.0%

diiodomethane (75-11-6) + 1-iodo-2,3-dimethoxybenzene (25245-33-4) → 4-iodobenzo[d][1,3]dioxole (849517-65-3)

Guidance literature:

1-iodo-2,3-dimethoxybenzene; With boron tribromide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

diiodomethane; With caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2011.03.002

Reference yield: 69.0%

4-iodo-5-(methoxymethoxy)-1,3-benzodioxole → 4-iodobenzo[d][1,3]dioxole (849517-65-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 45 ℃; for 3.5h; Inert atmosphere;

DOI:10.1002/hlca.201200439

upstream raw materials:

1,2-dimethoxybenzene

diiodomethane

1-iodo-2,3-dimethoxybenzene

3,4-(methylenedioxy)phenyl methoxymethyl ether

Downstream raw materials:

N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodobenzamide

N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodo-5-methoxybenzamide

Refernces

• 1、 -. "THERAPEUTIC AGENT FOR HEPATITIS C". . . Retrieved 2013/02/27.
• 2、 Aoyama, Hiroshi,Sugita, Kazuyuki,Nakamura, Masahiko,Aoyama, Atsushi,Salim, Mohammed T.A.,Okamoto, Mika,Baba, Masanori,Hashimoto, Yuichi. "Fused heterocyclic amido compounds as anti-hepatitis C virus agents". . p. 2675 - 2687. Retrieved 2011/06/11.