1-benzyl-2-[5-((tert-butyl)diphenylsilyloxy)pent-1-ynyl]-1-azaspiro[2.4]heptane

Base Information

Chemical Name:1-benzyl-2-[5-((tert-butyl)diphenylsilyloxy)pent-1-ynyl]-1-azaspiro[2.4]heptane
CAS No.:1312751-13-5
Molecular Formula:C₃₄H₄₁NOSi
Molecular Weight:507.791
Hs Code.:

Synonyms:1-benzyl-2-[5-((tert-butyl)diphenylsilyloxy)pent-1-ynyl]-1-azaspiro[2.4]heptane

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Chemical Property of 1-benzyl-2-[5-((tert-butyl)diphenylsilyloxy)pent-1-ynyl]-1-azaspiro[2.4]heptane

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Technology Process of 1-benzyl-2-[5-((tert-butyl)diphenylsilyloxy)pent-1-ynyl]-1-azaspiro[2.4]heptane

There total 3 articles about 1-benzyl-2-[5-((tert-butyl)diphenylsilyloxy)pent-1-ynyl]-1-azaspiro[2.4]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1312751-11-3
1-benzyl-2-ethynyl-1-azaspiro[2.4]heptane

: 177338-13-5
3-(tert-butyldiphenylsilyloxy)propyl bromide

: 1312751-13-5
1-benzyl-2-[5-((tert-butyl)diphenylsilyloxy)pent-1-ynyl]-1-azaspiro[2.4]heptane

Guidance literature:: 1-benzyl-2-ethynyl-1-azaspiro[2.4]heptane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

3-(tert-butyldiphenylsilyloxy)propyl bromide; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/jo201000f

Reference yield:

: 27721-47-7
N-cyclopentyl-1-phenylmethanimine

: 1312751-13-5
1-benzyl-2-[5-((tert-butyl)diphenylsilyloxy)pent-1-ynyl]-1-azaspiro[2.4]heptane

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc dibromide; lithium diisopropyl amide / tetrahydrofuran / -78 °C

1.2: -78 - 20 °C

2.1: potassium carbonate / methanol / 0.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

3.2: -78 - 20 °C

With n-butyllithium; potassium carbonate; zinc dibromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo201000f

Reference yield:

: 100-46-9
benzylamine

: 1312751-13-5
1-benzyl-2-[5-((tert-butyl)diphenylsilyloxy)pent-1-ynyl]-1-azaspiro[2.4]heptane

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

2.1: zinc dibromide; lithium diisopropyl amide / tetrahydrofuran / -78 °C

2.2: -78 - 20 °C

3.1: potassium carbonate / methanol / 0.5 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

4.2: -78 - 20 °C

With n-butyllithium; potassium carbonate; zinc dibromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jo201000f