2-((6S,7R,8aS)-8-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-isoindole-1,3-dione

Base Information

Chemical Name:2-((6S,7R,8aS)-8-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-isoindole-1,3-dione
CAS No.:129519-27-3
Molecular Formula:C₃₀H₂₉NO₆S
Molecular Weight:531.629
Hs Code.:

Synonyms:2-((6S,7R,8aS)-8-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-isoindole-1,3-dione

Suppliers and Price of 2-((6S,7R,8aS)-8-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-isoindole-1,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((6S,7R,8aS)-8-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-isoindole-1,3-dione

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of 2-((6S,7R,8aS)-8-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-isoindole-1,3-dione

There total 14 articles about 2-((6S,7R,8aS)-8-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 100-39-0
benzyl bromide

: 129519-28-4
2-((6S,7R,8aS)-6-ethylsulfanyl-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-isoindole-1,3-dione

: 129519-27-3
2-((6S,7R,8aS)-8-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-isoindole-1,3-dione

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 1h; Heating;
DOI:10.1016/0008-6215(93)87009-H

Reference yield: 51.0%

: 5573-62-6
(ethylthio)trimethylsilane

: 144221-80-7
1-O-Acetyl-3-O-benzyl-4,6-O-benzylidene-2-deoxy-2-phthalimido-β-D-allopyranose

: 123212-53-3,129519-27-3,144300-02-7
Ethyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-2-phthalimido-1-thio-β-D-allopyranoside

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1002/hlca.19920750505

Reference yield:

: 85-44-9
phthalic anhydride

: 123212-53-3,129519-27-3,144300-02-7
Ethyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-2-phthalimido-1-thio-β-D-allopyranoside

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / Et₃N / methanol / 0.5 h / Ambient temperature

2: 44 percent / NaH / dimethylformamide / 24 h / Ambient temperature

3: 1 M aq. NaOH / dioxane / 5 h / Ambient temperature

4: Ac₂O, pyridine / 48 h / Ambient temperature

5: hydrogen / 2)2>PF₆ / tetrahydrofuran / 3 h / Ambient temperature

6: water, HgO, HgCl₂ / acetone / 1 h / Ambient temperature

7: 97 percent / pyridine / 12 h / Ambient temperature

8: 51 percent / 4-Angstroem molecular sieves, trimethylsilyl triflate / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; water; hydrogen; acetic anhydride; sodium hydride; triethylamine; mercury dichloride; mercury(II) oxide; (1,5-cyclooctadiene)bis(methyldiphenylphosphine) iridium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1002/hlca.19920750505