N-<2(RS)-<(benzyloxyamino)carbonyl>-1-oxo-3-phenylpropyl>glycine benzylamide

Base Information

Chemical Name:N-<2(RS)-<(benzyloxyamino)carbonyl>-1-oxo-3-phenylpropyl>glycine benzylamide
CAS No.:96866-09-0
Molecular Formula:C₂₆H₂₇N₃O₄
Molecular Weight:445.518
Hs Code.:

Synonyms:N-<2(RS)-<(benzyloxyamino)carbonyl>-1-oxo-3-phenylpropyl>glycine benzylamide

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Chemical Property of N-<2(RS)-<(benzyloxyamino)carbonyl>-1-oxo-3-phenylpropyl>glycine benzylamide

Chemical Property:

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Technology Process of N-<2(RS)-<(benzyloxyamino)carbonyl>-1-oxo-3-phenylpropyl>glycine benzylamide

There total 4 articles about N-<2(RS)-<(benzyloxyamino)carbonyl>-1-oxo-3-phenylpropyl>glycine benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 67681-99-6
α-[(benzyloxy)carbamoyl]hydrocinnamic acid

: 81110-67-0
glycine benzylamide trifluoroacetate

: 96866-09-0
N-<2(RS)-<(benzyloxyamino)carbonyl>-1-oxo-3-phenylpropyl>glycine benzylamide

Guidance literature:: With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm00147a007

Reference yield:

: 2985-39-9,175521-78-5
2-benzylmalonic acid monoethyl ester

: 96866-09-0
N-<2(RS)-<(benzyloxyamino)carbonyl>-1-oxo-3-phenylpropyl>glycine benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / Et₃N, 1-hydroxybenzotriazole (HOBt), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

2: 64 percent / 2.5 N aq. NaOH / methanol / 4 h / Ambient temperature

3: 88 percent / Et₃N, 1-hydroxybenzotriazol (HOBT), N-cyclohexyl-N'-<2-(4-morpholinyl)ethyl>carbodiimide methol p-toluenosulfonate / tetrahydrofuran / Ambient temperature

With sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm00147a007

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 96866-09-0
N-<2(RS)-<(benzyloxyamino)carbonyl>-1-oxo-3-phenylpropyl>glycine benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / Et₃N, 1-hydroxybenzotriazole (HOBt), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

2: 64 percent / 2.5 N aq. NaOH / methanol / 4 h / Ambient temperature

3: 88 percent / Et₃N, 1-hydroxybenzotriazol (HOBT), N-cyclohexyl-N'-<2-(4-morpholinyl)ethyl>carbodiimide methol p-toluenosulfonate / tetrahydrofuran / Ambient temperature

With sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm00147a007