N-Formyl-L-sarcolysin

Base Information

• Chemical Name: N-Formyl-L-sarcolysin
• CAS No.: 35849-41-3
• Deprecated CAS: 32526-17-3
• Molecular Formula: C14H18Cl2N2O3
• Molecular Weight: 333.215
• NSC Number: 39274,37024
• DSSTox Substance ID: DTXSID00954256
• Nikkaji Number: J514.309H
• Mol file: 35849-41-3.mol

Synonyms:N-Formyl-L-sarcolysin;N-Formylmelphalan;N-Formylsarcolysine;CB 3208;N-Formyl-L-p-sarcolysin;NSC 37024;L-3-(p-(Bis(2-chloroethyl)amino)phenyl)-N-formylalanine;L-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-N-formyl-;Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-N-formyl-, (-)-;ALANINE, 3-(p-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-N-FORMYL-, L-;L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-N-formyl-;DL-Phenylalanine, 4-[bis(2-chloroethyl)amino]-N-formyl-;L-Alanine, 3-(p-[bis(2-chloroethyl)amino]phenyl)-N-formyl-;C14H18Cl2N2O3;L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-N-formyl-;Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-N-formyl-, L-;NFormylmelphalan;C14-H18-Cl2-N2-O3;N-Formyl-DL-sarcolysin;26367-45-3;Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-N-formyl-, DL-;DTXSID00954256;NSC37024;NSC39274;MP 506;NSC-37024;NSC-39274;LS-15879;HY-147327;CS-0565883;DL-Alanine, 3-[p-bis(2-chloroethyl)aminophenyl]-N-formyl-;4-[Bis(2-chloroethyl)amino]-N-(hydroxymethylidene)phenylalanine;32526-17-3

Chemical Property of N-Formyl-L-sarcolysin

Chemical Property:

• Refractive Index: 1.6140 (estimate)
• Boiling Point: 580.1°Cat760mmHg
• Flash Point: 304.6°C
• PSA: 69.64000
• Density: 1.331g/cm³
• LogP: 2.73910
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 332.0694478
• Heavy Atom Count: 21
• Complexity: 317

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(C(=O)O)NC=O)N(CCCl)CCCl

Technology Process of N-Formyl-L-sarcolysin

There total 2 articles about N-Formyl-L-sarcolysin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

formic acid (64-18-6) + L-PAM (148-82-3,8057-25-8) → formylmerphalan (35849-41-3)

Guidance literature:

With acetic anhydride; at 50 ℃; for 5h;

DOI:10.1021/ml500141f

Reference yield:

L-PAM (148-82-3,8057-25-8) → formylmerphalan (35849-41-3)

Guidance literature:

With acetic anhydride; In formic acid;

Reference yield: 61.0%

formylmerphalan (35849-41-3) + C11H11NO2 → (S)-3-(4-(bis(2-chloroethyl)amino)phenyl)-2-formamido-N-((6-methyl-4-oxo-4H-chromen-3-yl)methyl)propanamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1080/14756366.2021.2018685

upstream raw materials:

formic acid

L-PAM

Downstream raw materials:

ethyl (S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoate

N-Formyl-p--L-phenylalanin-amid

(N-Formyl-melphalanyl)-glycin-ethylester