(S)-5-hydroxy-2-methyl-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinolin-4(1H)-one

Base Information

Chemical Name:(S)-5-hydroxy-2-methyl-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinolin-4(1H)-one
CAS No.:1429484-72-9
Molecular Formula:C₂₁H₂₅NO₃
Molecular Weight:339.434
Hs Code.:

Synonyms:(S)-5-hydroxy-2-methyl-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinolin-4(1H)-one

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Chemical Property of (S)-5-hydroxy-2-methyl-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinolin-4(1H)-one

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Technology Process of (S)-5-hydroxy-2-methyl-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinolin-4(1H)-one

There total 9 articles about (S)-5-hydroxy-2-methyl-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (S)-5-phenyl-2-pentanol mesylate

: 65511-03-7
(S)-5,7-dihydroxy-2-methyl-2,3-dihydroquinolin-4(1H)-one

: 1429484-72-9
(S)-5-hydroxy-2-methyl-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinolin-4(1H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 82 ℃; for 2.5h; Inert atmosphere;
DOI:10.1039/c3cc41388h

Reference yield:

: 87025-89-6
5-phenyl-2-pentanol phthalate

: 1429484-72-9
(S)-5-hydroxy-2-methyl-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: ethyl acetate / 60 °C / Resolution of racemate

2: hydrogenchloride; water / diethyl ether / 0.08 h / 20 °C

3: water; sodium hydroxide / 0.08 h / Reflux

4: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 - 82 °C / Inert atmosphere

With hydrogenchloride; water; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c3cc41388h

Reference yield:

: 2344-71-0
5-phenylpentan-2-ol

: 1429484-72-9
(S)-5-hydroxy-2-methyl-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 4.5 h / 20 - 96 °C

2: ethyl acetate / 60 °C / Resolution of racemate

3: hydrogenchloride; water / diethyl ether / 0.08 h / 20 °C

4: water; sodium hydroxide / 0.08 h / Reflux

5: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

6: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 - 82 °C / Inert atmosphere

With pyridine; hydrogenchloride; water; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c3cc41388h