(6S,6aR,10aR)-5,6,6a,7,10,10a-hexahydro-1-acetoxy-6-methyl-3-[(R)-5-phenyl-2-pentyloxy]benzo[c]quinoline-9(8H)-one

Base Information

Chemical Name:(6S,6aR,10aR)-5,6,6a,7,10,10a-hexahydro-1-acetoxy-6-methyl-3-[(R)-5-phenyl-2-pentyloxy]benzo[c]quinoline-9(8H)-one
CAS No.:1429484-74-1
Molecular Formula:C₂₇H₃₃NO₄
Molecular Weight:435.563
Hs Code.:

Synonyms:(6S,6aR,10aR)-5,6,6a,7,10,10a-hexahydro-1-acetoxy-6-methyl-3-[(R)-5-phenyl-2-pentyloxy]benzo[c]quinoline-9(8H)-one

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Chemical Property of (6S,6aR,10aR)-5,6,6a,7,10,10a-hexahydro-1-acetoxy-6-methyl-3-[(R)-5-phenyl-2-pentyloxy]benzo[c]quinoline-9(8H)-one

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Technology Process of (6S,6aR,10aR)-5,6,6a,7,10,10a-hexahydro-1-acetoxy-6-methyl-3-[(R)-5-phenyl-2-pentyloxy]benzo[c]quinoline-9(8H)-one

There total 16 articles about (6S,6aR,10aR)-5,6,6a,7,10,10a-hexahydro-1-acetoxy-6-methyl-3-[(R)-5-phenyl-2-pentyloxy]benzo[c]quinoline-9(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₃₁NO₃

: 108-24-7
acetic anhydride

: 1429484-74-1
(6S,6aR,10aR)-5,6,6a,7,10,10a-hexahydro-1-acetoxy-6-methyl-3-[(R)-5-phenyl-2-pentyloxy]benzo[c]quinoline-9(8H)-one

Guidance literature:: C₂₅H₃₁NO₃; With dmap; triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

acetic anhydride; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c3cc41388h

Reference yield:

: 1429484-72-9
(S)-5-hydroxy-2-methyl-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinolin-4(1H)-one

: 1429484-74-1
(6S,6aR,10aR)-5,6,6a,7,10,10a-hexahydro-1-acetoxy-6-methyl-3-[(R)-5-phenyl-2-pentyloxy]benzo[c]quinoline-9(8H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / toluene; mineral oil / 0.08 h / 20 °C / Inert atmosphere

1.2: 20 h / 20 °C

2.1: triethylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

2.2: 4 h / 0 °C

3.1: sodium / methanol / 48 h / Reflux; Inert atmosphere

4.1: ammonia; lithium / tetrahydrofuran / 0.33 h / -70 °C / Inert atmosphere

5.1: triethylamine; dmap / dichloromethane / 0 °C / Inert atmosphere

5.2: 1 h / 0 °C / Inert atmosphere

With dmap; ammonia; sodium; lithium; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; mineral oil;
DOI:10.1039/c3cc41388h

Reference yield:

: 1429484-73-0
(2S)-1-formyl-5-hydroxy-2-methyl-4-oxo-3-(3-oxobutyl)-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinoline

: 1429484-74-1
(6S,6aR,10aR)-5,6,6a,7,10,10a-hexahydro-1-acetoxy-6-methyl-3-[(R)-5-phenyl-2-pentyloxy]benzo[c]quinoline-9(8H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium / methanol / 48 h / Reflux; Inert atmosphere

2.1: ammonia; lithium / tetrahydrofuran / 0.33 h / -70 °C / Inert atmosphere

3.1: triethylamine; dmap / dichloromethane / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

With dmap; ammonia; sodium; lithium; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/c3cc41388h