(2S)-1-formyl-5-hydroxy-2-methyl-4-oxo-3-(3-oxobutyl)-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinoline

Base Information

Chemical Name:(2S)-1-formyl-5-hydroxy-2-methyl-4-oxo-3-(3-oxobutyl)-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinoline
CAS No.:1429484-73-0
Molecular Formula:C₂₆H₃₁NO₅
Molecular Weight:437.536
Hs Code.:

Synonyms:

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Chemical Property of (2S)-1-formyl-5-hydroxy-2-methyl-4-oxo-3-(3-oxobutyl)-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinoline

Chemical Property:

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Technology Process of (2S)-1-formyl-5-hydroxy-2-methyl-4-oxo-3-(3-oxobutyl)-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinoline

There total 13 articles about (2S)-1-formyl-5-hydroxy-2-methyl-4-oxo-3-(3-oxobutyl)-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₅NO₅

: C₂₂H₂₅NO₄

: 78-94-4,25038-87-3
methyl vinyl ketone

: 1429484-73-0
(2S)-1-formyl-5-hydroxy-2-methyl-4-oxo-3-(3-oxobutyl)-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinoline

Guidance literature:: C₂₃H₂₅NO₅; C₂₂H₂₅NO₄; methyl vinyl ketone; With triethylamine; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;

With potassium carbonate; In methanol; at 0 ℃; for 4h;
DOI:10.1039/c3cc41388h

Reference yield:

: 65511-03-7
(S)-5,7-dihydroxy-2-methyl-2,3-dihydroquinolin-4(1H)-one

: 1429484-73-0
(2S)-1-formyl-5-hydroxy-2-methyl-4-oxo-3-(3-oxobutyl)-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 - 82 °C / Inert atmosphere

2.1: sodium hydride / toluene; mineral oil / 0.08 h / 20 °C / Inert atmosphere

2.2: 20 h / 20 °C

3.1: triethylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

3.2: 4 h / 0 °C

With sodium hydride; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c3cc41388h

Reference yield:

: 2344-71-0
5-phenylpentan-2-ol

: 1429484-73-0
(2S)-1-formyl-5-hydroxy-2-methyl-4-oxo-3-(3-oxobutyl)-7-[(R)-5-phenyl-2-pentyloxy]-2,3-dihydroquinoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / 4.5 h / 20 - 96 °C

2.1: ethyl acetate / 60 °C / Resolution of racemate

3.1: hydrogenchloride; water / diethyl ether / 0.08 h / 20 °C

4.1: water; sodium hydroxide / 0.08 h / Reflux

5.1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 - 82 °C / Inert atmosphere

7.1: sodium hydride / toluene; mineral oil / 0.08 h / 20 °C / Inert atmosphere

7.2: 20 h / 20 °C

8.1: triethylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

8.2: 4 h / 0 °C

With pyridine; hydrogenchloride; water; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c3cc41388h