N¹-monobenzyl,N²-Boc-(1R,2R)-diaminocyclohexane

Base Information

Chemical Name:N¹-monobenzyl,N²-Boc-(1R,2R)-diaminocyclohexane
CAS No.:1354486-21-7
Molecular Formula:C₁₈H₂₈N₂O₂
Molecular Weight:304.433
Hs Code.:

N<SUP>1</SUP>-monobenzyl,N<SUP>2</SUP>-Boc-(1R,2R)-diaminocyclohexane

Synonyms:N¹-monobenzyl,N²-Boc-(1R,2R)-diaminocyclohexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N¹-monobenzyl,N²-Boc-(1R,2R)-diaminocyclohexane

Chemical Property:

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Technology Process of N¹-monobenzyl,N²-Boc-(1R,2R)-diaminocyclohexane

There total 4 articles about N¹-monobenzyl,N²-Boc-(1R,2R)-diaminocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: C₁₈H₂₆N₂O₂

: 1354486-21-7,1217764-63-0
N¹-monobenzyl,N²-Boc-(1R,2R)-diaminocyclohexane

Guidance literature:: With sodium cyanoborohydride; In methanol; for 18h; Molecular sieve; Inert atmosphere;
DOI:10.1021/ol302354z DOI:10.1021/ol302354z

Reference yield:

: 100-52-7
benzaldehyde

: 146504-07-6
tert-butyl ((1R,2R)-2-aminocyclohexyl)carbamate

: 1354486-21-7,1217764-63-0
N¹-monobenzyl,N²-Boc-(1R,2R)-diaminocyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / methanol / 1.33 h / Molecular sieve; Inert atmosphere

2: sodium cyanoborohydride / methanol / 18 h / Molecular sieve; Inert atmosphere

With sodium cyanoborohydride; acetic acid; In methanol;
DOI:10.1021/ol302354z DOI:10.1021/ol302354z

Reference yield:

: 100-52-7
benzaldehyde

: 1354486-21-7,1217764-63-0
N¹-monobenzyl,N²-Boc-(1R,2R)-diaminocyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 0.5 h / 20 °C

2: sodium tetrahydroborate / methanol / 2.5 h / 0 °C

With sodium tetrahydroborate; In methanol;
DOI:10.1016/j.tetasy.2013.09.026