(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

Base Information

Chemical Name:(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide
CAS No.:157662-70-9
Molecular Formula:C₂₂H₂₆FN₃O₆
Molecular Weight:447.463
Hs Code.:

Synonyms:(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

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Technology Process of (2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

There total 9 articles about (2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 160877-33-8
(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-hydroxyphenylacetamide

: 74-88-4
methyl iodide

: 157662-70-9
(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

Guidance literature:: With potassium carbonate; In acetone; for 1h; Ambient temperature;
DOI:10.1021/jo00098a010

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 157662-70-9
(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: NaBH₄

2: PBr₃

3: 83.9 percent / acetonitrile / 4 h / Ambient temperature

4: 50.2 percent / NaBH₄, TFA / tetrahydrofuran / 15 h / Ambient temperature

5: 72 percent / DCC, 1-hydroxybenzotriazole / dimethylformamide; CH₂Cl₂ / 12 h / Ambient temperature

6: 80 percent / K₂CO₃ / acetone / 1 h / Ambient temperature

With sodium tetrahydroborate; phosphorus tribromide; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jo00098a010

Reference yield:

: 20274-69-5
(4-fluoro-3-nitrophenyl)methanol

: 157662-70-9
(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: PBr₃

2: 83.9 percent / acetonitrile / 4 h / Ambient temperature

3: 50.2 percent / NaBH₄, TFA / tetrahydrofuran / 15 h / Ambient temperature

4: 72 percent / DCC, 1-hydroxybenzotriazole / dimethylformamide; CH₂Cl₂ / 12 h / Ambient temperature

5: 80 percent / K₂CO₃ / acetone / 1 h / Ambient temperature

With sodium tetrahydroborate; phosphorus tribromide; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jo00098a010