5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one

Base Information

• Chemical Name: 5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one
• CAS No.: 1182402-79-4
• Molecular Formula: C₁₉H₁₈Cl₃NO₂
• Molecular Weight: 398.716
• Mol file: 1182402-79-4.mol

Synonyms:5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one

Chemical Property of 5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one

There total 4 articles about 5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobutyl bromide (6940-78-9) + 5-chloro-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one (352278-00-3) → 5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one (1182402-79-4)

Guidance literature:

5-chloro-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one; With potassium tert-butylate; In N,N-dimethyl-formamide; at -50 - -20 ℃; Inert atmosphere;

4-chlorobutyl bromide; In N,N-dimethyl-formamide; at -50 - 10 ℃; for 16h;

Reference yield:

1-chloro-5-fluoro-2-methoxy-4-nitrobenzene (84478-76-2) → 5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one (1182402-79-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil / 1 h / -5 - 3 °C

2.1: acetic acid; iron / methanol / 16 h / Reflux

3.1: potassium tert-butylate / N,N-dimethyl-formamide / -50 - -20 °C / Inert atmosphere

3.2: 16 h / -50 - 10 °C

With potassium tert-butylate; iron; sodium hydride; acetic acid; In methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

methyl (2-chlorophenyl)acetate (57486-68-7) → 5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one (1182402-79-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil / 1 h / -5 - 3 °C

2.1: acetic acid; iron / methanol / 16 h / Reflux

3.1: potassium tert-butylate / N,N-dimethyl-formamide / -50 - -20 °C / Inert atmosphere

3.2: 16 h / -50 - 10 °C

With potassium tert-butylate; iron; sodium hydride; acetic acid; In methanol; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

4-chlorobutyl bromide

5-chloro-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one

methyl (2-chlorophenyl)acetate

1-chloro-5-fluoro-2-methoxy-4-nitrobenzene

Downstream raw materials:

5-Chloro-3-(2-chlorophenyl)-3-[4-(dimethylamino)butyl]-6-methoxy-1,3-dihydro-2H-indol-2-one