methyl 7-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoate

Base Information

• Chemical Name: methyl 7-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoate
• CAS No.: 1586025-48-0
• Molecular Formula: C₂₅H₂₉NO₅S
• Molecular Weight: 455.575

Synonyms:methyl 7-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoate

Chemical Property of methyl 7-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoate

Chemical Property:

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Technology Process of methyl 7-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoate

There total 4 articles about methyl 7-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate (186787-88-2) + methyl 7-aminoheptanoate hydrochloride (17994-94-4) → methyl 7-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoate (1586025-48-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 24h; Inert atmosphere;

DOI:10.1002/cmdc.201300270

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → methyl 7-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoate (1586025-48-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: bromine / chloroform / 0.17 h / 50 °C / Inert atmosphere

2.1: n-butyllithium / hexane / 2 h / -78 °C / Inert atmosphere

2.2: Inert atmosphere

2.3: Inert atmosphere

3.1: thionyl chloride / toluene / 2 h / Reflux; Inert atmosphere

4.1: triethylamine / dichloromethane / 24 h / 0 °C / Inert atmosphere

With n-butyllithium; thionyl chloride; bromine; triethylamine; In hexane; dichloromethane; chloroform; toluene;

DOI:10.1002/cmdc.201300270

Reference yield:

6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxylic acid → methyl 7-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoate (1586025-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 2 h / Reflux; Inert atmosphere

2: triethylamine / dichloromethane / 24 h / 0 °C / Inert atmosphere

With thionyl chloride; triethylamine; In dichloromethane; toluene;

DOI:10.1002/cmdc.201300270

upstream raw materials:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate

methyl 7-aminoheptanoate hydrochloride

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

Downstream raw materials:

6-hydroxy-N-(7-(hydroxyamino)-7-oxoheptyl)-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carboxamide

6-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoic acid

methyl 7-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoate

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