methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate

Base Information

• Chemical Name: methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate
• CAS No.: 186787-88-2
• Molecular Formula: C₁₇H₁₃ClO₃S
• Molecular Weight: 332.807

Synonyms:methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate

Chemical Property of methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate

Chemical Property:

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Technology Process of methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate

There total 3 articles about methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxylic acid → methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate (186787-88-2)

Guidance literature:

With thionyl chloride; In toluene; for 2h; Time; Reflux; Inert atmosphere;

DOI:10.1002/cmdc.201300270

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate (186787-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: bromine / chloroform / 0.17 h / 50 °C / Inert atmosphere

2.1: n-butyllithium / hexane / 2 h / -78 °C / Inert atmosphere

2.2: Inert atmosphere

2.3: Inert atmosphere

3.1: thionyl chloride / toluene / 2 h / Reflux; Inert atmosphere

With n-butyllithium; thionyl chloride; bromine; In hexane; chloroform; toluene;

DOI:10.1002/cmdc.201300270

Reference yield:

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (176672-06-3) → methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate (186787-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane / 2 h / -78 °C / Inert atmosphere

1.2: Inert atmosphere

1.3: Inert atmosphere

2.1: thionyl chloride / toluene / 2 h / Reflux; Inert atmosphere

With n-butyllithium; thionyl chloride; In hexane; toluene;

DOI:10.1002/cmdc.201300270

upstream raw materials:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

Downstream raw materials:

[6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone

methyl 7-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)heptanoate

methyl 6-(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamido)hexanoate

6-hydroxy-N-(6-(hydroxyamino)-6-oxohexyl)-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carboxamide

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