allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoate

Base Information

• Chemical Name: allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoate
• CAS No.: 208655-83-8
• Molecular Formula: C₃₁H₃₃NO₅
• Molecular Weight: 499.607
• Mol file: 208655-83-8.mol

Synonyms:allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoate

Chemical Property of allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoate

There total 2 articles about allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + allyl bromide (106-95-6) → allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoate (208655-83-8)

Guidance literature:

Fmoc-Tyr(tBu)-OH; With silver carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

allyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;

DOI:10.1002/psc.2508

Reference yield: 82.0%

Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + allyl alcohol (107-18-6) → allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoate (208655-83-8)

Guidance literature:

Fmoc-Tyr(tBu)-OH; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.333333h;

allyl alcohol; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1002/ejoc.201500697

Reference yield: 100.0%

allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoate (208655-83-8) → (S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-hydroxyphenyl)propanoate (143674-78-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/psc.2508

upstream raw materials:

Fmoc-Tyr(tBu)-OH

allyl bromide

allyl alcohol

Downstream raw materials:

(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-hydroxyphenyl)propanoate

(S)-allyl 2-amino-3-(4-(tert-butoxy)phenyl)propanoate

Fmoc-Pro-Ser(O-t-Bu)-Tyr(O-t-Bu)-OAll

Lys(ε-Boc)-Pro-Ser(O-t-Bu)-Tyr(O-t-Bu)-OAll