di-tert-butyl N--D-phenylalaninate

Base Information

Chemical Name:di-tert-butyl N--D-phenylalaninate
CAS No.:145789-00-0
Molecular Formula:C₃₀H₄₀N₂O₇
Molecular Weight:540.657
Hs Code.:

di-tert-butyl N-<N-(benzyloxycarbonyl)-L-γ-glutamyl>-D-phenylalaninate

Synonyms:di-tert-butyl N--D-phenylalaninate

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Chemical Property of di-tert-butyl N--D-phenylalaninate

Chemical Property:

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Technology Process of di-tert-butyl N--D-phenylalaninate

There total 3 articles about di-tert-butyl N--D-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 145789-00-0
di-tert-butyl N--D-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / conc. H₂SO₄ / CH₂Cl₂ / 28 h / Ambient temperature

2: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / Ambient temperature

3: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) RT, 1.5 h

With 4-methyl-morpholine; sulfuric acid; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jm950471+

Reference yield:

: 112924-08-0
tert-butyl N-(benzyloxycarbonyl)-D-phenylalaninate

: 145789-00-0
di-tert-butyl N--D-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / Ambient temperature

2: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) RT, 1.5 h

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm950471+

Reference yield:

: 5891-45-2
(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

: 3081-28-5,6404-30-4,16367-71-8,16874-17-2
D-phenylalanine tert-butyl ester

: 145789-00-0
di-tert-butyl N--D-phenylalaninate

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) RT, 1.5 h;
DOI:10.1021/jm950471+