(S)-4-((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester

Base Information

Chemical Name:(S)-4-((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester
CAS No.:145789-01-1
Molecular Formula:C₄₂H₄₉N₅O₇
Molecular Weight:735.88
Hs Code.:

(S)-4-((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester

Synonyms:(S)-4-((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester

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Chemical Property of (S)-4-((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester

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Technology Process of (S)-4-((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester

There total 5 articles about (S)-4-((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 138899-84-0
4--N-prop-2-ynylamino>benzoic acid, trifluoroacetate salt

: 172793-43-0
di-tert-butyl L-γ-glutamyl-D-phenylalaninate

: 145789-01-1
(S)-4-((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester

Guidance literature:: With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.16667h;
DOI:10.1021/jm950471+

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 145789-01-1
(S)-4-((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / conc. H₂SO₄ / CH₂Cl₂ / 28 h / Ambient temperature

2: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / Ambient temperature

3: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) RT, 1.5 h

4: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / Ambient temperature

5: 57 percent / DEPC, Et₃N / dimethylformamide / 2.17 h / 0 - 20 °C

With 4-methyl-morpholine; sulfuric acid; hydrogen; triethylamine; diethyl dicarbonate; isobutyl chloroformate; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950471+

Reference yield:

: 112924-08-0
tert-butyl N-(benzyloxycarbonyl)-D-phenylalaninate

: 145789-01-1
(S)-4-((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / Ambient temperature

2: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) RT, 1.5 h

3: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / Ambient temperature

4: 57 percent / DEPC, Et₃N / dimethylformamide / 2.17 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogen; triethylamine; diethyl dicarbonate; isobutyl chloroformate; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950471+