(2R,7R,8R)-3-Methylene-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]nonane-2,5,5-tricarboxylic acid dimethyl ester 4-nitro-benzyl ester

Base Information

Chemical Name:(2R,7R,8R)-3-Methylene-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]nonane-2,5,5-tricarboxylic acid dimethyl ester 4-nitro-benzyl ester
CAS No.:130994-93-3
Molecular Formula:C₂₈H₂₇N₃O₁₁S
Molecular Weight:613.602
Hs Code.:

(2R,7R,8R)-3-Methylene-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]nonane-2,5,5-tricarboxylic acid dimethyl ester 4-nitro-benzyl ester

Synonyms:(2R,7R,8R)-3-Methylene-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]nonane-2,5,5-tricarboxylic acid dimethyl ester 4-nitro-benzyl ester

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Chemical Property of (2R,7R,8R)-3-Methylene-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]nonane-2,5,5-tricarboxylic acid dimethyl ester 4-nitro-benzyl ester

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Technology Process of (2R,7R,8R)-3-Methylene-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]nonane-2,5,5-tricarboxylic acid dimethyl ester 4-nitro-benzyl ester

There total 1 articles about (2R,7R,8R)-3-Methylene-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]nonane-2,5,5-tricarboxylic acid dimethyl ester 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 60761-30-0
(6R)-3-methylene-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester

: 6773-29-1
dimethyl diazomalonate

: 130994-93-3
(2R,7R,8R)-3-Methylene-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]nonane-2,5,5-tricarboxylic acid dimethyl ester 4-nitro-benzyl ester

Guidance literature:: With copper(II) sulfate; In various solvent(s); Heating;

Reference yield: 92.0%

: 130994-93-3
(2R,7R,8R)-3-Methylene-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]nonane-2,5,5-tricarboxylic acid dimethyl ester 4-nitro-benzyl ester

: (7R,8R)-3-Methyl-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]non-2-ene-2,5,5-tricarboxylic acid dimethyl ester 4-nitro-benzyl ester

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: 130994-93-3
(2R,7R,8R)-3-Methylene-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]nonane-2,5,5-tricarboxylic acid dimethyl ester 4-nitro-benzyl ester

: 130994-97-7
(7R,8R)-3-Methyl-9-oxo-8-(2-phenoxy-acetylamino)-6-thia-1-aza-bicyclo[5.2.0]non-2-ene-2,5,5-tricarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / Et₃N / CH₂Cl₂

2: 84 percent / H₂ / Pd/C / tetrahydrofuran; methanol

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;