3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester

Base Information

• Chemical Name: 3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester
• CAS No.: 1202273-87-7
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.272
• Mol file: 1202273-87-7.mol

Synonyms:3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester

Chemical Property of 3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester

There total 3 articles about 3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 3-hydroxy-2,2-dimethyl-3-(4-nitrophenyl)propionate → 3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester (1202273-87-7)

Guidance literature:

With palladium on carbon; hydrogen; In ethanol; for 0.5h;

DOI:10.1021/jm101583w

Reference yield:

4-nitrobenzaldehdye (555-16-8) → 3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester (1202273-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine N-oxide; lithium chloride / N,N-dimethyl-formamide / 18 h

2: palladium on carbon; hydrogen / ethanol / 0.5 h

With pyridine N-oxide; palladium on carbon; hydrogen; lithium chloride; In ethanol; N,N-dimethyl-formamide; 1: Mukaiyama aldol condensation;

DOI:10.1021/jm101583w

Reference yield:

1-methoxy-2-methyl-1-trimethylsiloxy-1-propene (31469-15-5) → 3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester (1202273-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine N-oxide; lithium chloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

With pyridine N-oxide; palladium on activated charcoal; hydrogen; lithium chloride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1039/c9ra01277j

upstream raw materials:

4-nitrobenzaldehdye

1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

Downstream raw materials:

3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester

3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-1-ylamino)phenyl]propionic acid methyl ester

3-hydroxy-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]-2,2-dimethylpropionic acid methyl ester

3-[4-(2-ethoxynaphthalen-1-ylamino)phenyl]-3-hydroxy-2,2-dimethylpropionic acid methyl ester