3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester

Base Information

Chemical Name:3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester
CAS No.:1202273-88-8
Molecular Formula:C₂₂H₂₃NO₃
Molecular Weight:349.43
Hs Code.:

Synonyms:3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester

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Chemical Property of 3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester

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Technology Process of 3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester

There total 3 articles about 3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1202273-87-7
3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester

: 32316-92-0
naphthalene-2-boronic acid

: 1202273-88-8
3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester

Guidance literature:: With pyridine; copper diacetate; In dichloromethane; at 20 ℃; for 48h; Molecular sieve; Air;
DOI:10.1021/jm101583w

Reference yield:

: methyl 3-hydroxy-2,2-dimethyl-3-(4-nitrophenyl)propionate

: 1202273-88-8
3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen / ethanol / 0.5 h

2: pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve; Air

With pyridine; palladium on carbon; hydrogen; copper diacetate; In ethanol; dichloromethane; 2: Suzuki coupling;
DOI:10.1021/jm101583w

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1202273-88-8
3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine N-oxide; lithium chloride / N,N-dimethyl-formamide / 18 h

2: palladium on carbon; hydrogen / ethanol / 0.5 h

3: pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve; Air

With pyridine; pyridine N-oxide; palladium on carbon; hydrogen; copper diacetate; lithium chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Mukaiyama aldol condensation / 3: Suzuki coupling;
DOI:10.1021/jm101583w